{"paper":{"title":"Synergistic interplay of morphology and metabolic activity rule response to CAR-T cells in B-cell lymphomas","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Alejandro Mart\\'in-Sancho, Alvaro M\\'art\\'inez-Rubio, Angel Cedillo, Antonio P\\'erez-Mart\\'inez, Carlos Montes-Fuentes, Christina Kuttler, J. Cristobal Ca\\~nadas Salazar, Juan Belmonte-Beitia, Lourdes Mart\\'in-Mart\\'in, Luc\\'ia L\\'opez-Corral, M. Pilar Tamayo-Alonso, Pascual Balsalobre, Pere Barba, Soukaina Sabir, V\\'ictor M. P\\'erez-Garc\\'ia, Yifan Chen","submitted_at":"2025-05-17T08:20:07Z","abstract_excerpt":"Cellular immunotherapies are one of the mainstream cancer treatments unveiling the power of the patient's immune system to fight tumors. CAR T-cell therapy, based on genetically engineered T cells, has demonstrated significant potential in treating hematological malignancies, including B-cell lymphomas. This treatment has complex longitudinal dynamics due to the interplay of different T-cell phenotypes (e.g. effector and memory), the expansion of the drug and the cytotoxic effect on both normal and cancerous B-cells, the exhaustion of the immune cells, the tumor immunosupressive environments, "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.11894","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.11894/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}