{"paper":{"title":"Does EDPVR Represent Myocardial Tissue Stiffness? Toward a Better Definition","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"physics.med-ph","authors_text":"Emilio A. Mendiola, Gaurav Choudhary, Rana Raza Mehdi, Reza Avazmohammadi, Vahid Naeini","submitted_at":"2024-07-21T19:54:45Z","abstract_excerpt":"Accurate assessment of myocardial tissue stiffness is pivotal for the diagnosis and prognosis of heart diseases. Left ventricular diastolic stiffness ($\\beta$) obtained from the end-diastolic pressure-volume relationship (EDPVR) has conventionally been utilized as a representative metric of myocardial stiffness. The EDPVR can be employed to estimate the intrinsic stiffness of myocardial tissues through image-based in-silico inverse optimization. However, whether $\\beta$, as an organ-level metric, accurately represents the tissue-level myocardial tissue stiffness in healthy and diseased myocard"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2407.15254","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2407.15254/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}