{"paper":{"title":"Data-Driven Tight Frame for Cryo-EM Image Denoising and Conformational Classification","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["eess.IV"],"primary_cat":"stat.CO","authors_text":"Hanlin Gu, Jian-Feng Cai, Wei Wang, Xuhui Huang, Yang Wang, Yin Xian, Yuan Yao","submitted_at":"2018-10-20T17:07:40Z","abstract_excerpt":"The cryo-electron microscope (cryo-EM) is increasingly popular these years. It helps to uncover the biological structures and functions of macromolecules. In this paper, we address image denoising problem in cryo-EM. Denoising the cryo-EM images can help to distinguish different molecular conformations and improve three dimensional reconstruction resolution. We introduce the use of data-driven tight frame (DDTF) algorithm for cryo-EM image denoising. The DDTF algorithm is closely related to the dictionary learning. The advantage of DDTF algorithm is that it is computationally efficient, and ca"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.08829","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}