{"paper":{"title":"Identification of the key parameters in a mathematical model of PAR1-mediated signaling in endothelial cells","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Emmanuele DiBenedetto, Heidi E. Hamm, Leonardo Lenoci","submitted_at":"2011-01-17T14:02:07Z","abstract_excerpt":"Biophysical models are often populated by a large number of input parameters that are difficult to predict or measure experimentally. The validity and robustness of a given model can be evaluated by a sensitivity test to its input parameters. In this study, we performed local (based on a Taylor-like method) and global sensitivity (based on Monte Carlo filtering techniques) analyses of a previously derived PAR1-mediated activation model of endothelial cells. This activation model previously demonstrated that peptide-activated PAR1 has a different receptor/G-protein binding affinity that favors "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1101.3215","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}