{"paper":{"title":"ChromoSkein: Untangling Three-Dimensional Chromatin Fiber With a Web-Based Visualization Framework","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.GR"],"primary_cat":"cs.HC","authors_text":"Barbora Kozl\\'ikov\\'a, David Kou\\v{r}il, Filip Op\\'alen\\'y, Jan By\\v{s}ka, Katar\\'ina Furmanov\\'a, Mat\\'u\\v{s} Tal\\v{c}\\'ik, Tereza Clarence","submitted_at":"2022-11-09T12:37:52Z","abstract_excerpt":"We present ChromoSkein, a web-based tool for visualizing three-dimensional chromatin models. The spatial organization of chromatin is essential to its function. Experimental methods, namely Hi-C, reveal the spatial conformation but output a 2D matrix representation. Biologists leverage simulation to bring this information back to 3D, assembling a 3D chromatin shape prediction using the 2D matrices as constraints. Our overview of existing chromatin visualization software shows that the available tools limit the utility of 3D through ineffective shading and a lack of advanced interactions. We de"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2211.05125","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2211.05125/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}