{"paper":{"title":"Circulating tumor cell detection in cancer patients using in-flow deep learning holography","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":["physics.med-ph"],"primary_cat":"physics.optics","authors_text":"Alexa Hesch, Ali Arafa, Arjun Viswanathan, Badrinath R. Konety, Catalina Galeano-Garces, Emmanuel S. Antonarakis, Grant Schaap, Ivo Babris, Jeffrey Miller, Jiarong Hong, Joel Hapke, Justin M. Drake, Kaylee Kamalanathan, Kevin Mallery, Mahdi Ahmadi, Nathaniel R. Bristow, Nicholas Heller, Olivia Hedeen, Songyi Bae, Tony Clacko, Tuan Le, Yash Travadi, Zikora Izuora","submitted_at":"2025-07-09T04:36:59Z","abstract_excerpt":"Circulating tumor cells (CTCs) are cancer cells found in the bloodstream that serve as biomarkers for early cancer detection, prognostication, and disease monitoring. However, CTC detection remains challenging due to low cell abundance and heterogeneity. Digital holographic microscopy (DHM) offers a promising, label-free method for high-throughput CTC identification by capturing superior morphological information compared to traditional imaging methods, while remaining compatible with in-flow data acquisition. We present a streamlined DHM-based system that integrates microfluidic enrichment wi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.06536","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2507.06536/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}