{"paper":{"title":"Evaluation of In Vivo Subject-Specific Mechanical Modeling of the Optic Nerve Head for Robust Assessment of Ocular Mechanics","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["physics.bio-ph","physics.comp-ph"],"primary_cat":"physics.med-ph","authors_text":"Amin Pourasghar, Chhavi Saini, John C. Brigham, Lucy Q. Shen, Mengyu Wang, Soumaya Ouhsousou","submitted_at":"2025-04-30T16:05:50Z","abstract_excerpt":"To establish the tissue regions necessary to accurately represent the mechanics of the optic nerve head (ONH), imaging data of the ONH from 2 healthy subjects were used to create in vivo subject-specific eye mechanical models considering distinct properties for all major ocular tissues. Tests were performed to evaluate the effect of the material properties and the inclusion of these tissues on the mechanics of the lamina cribrosa (LC), retina, and optic nerve. Then, the LC mechanical response due to variations in intraocular and intracranial pressures was evaluated to validate the modeling app"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2504.21765","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2504.21765/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}