{"paper":{"title":"Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Ad\\`ele Gerdil (LFP - URA 2453), Alain Van Dorsselaer (LSMBO-DSA-IPHC), Aur\\'elie Habert (LFP - URA 2453), Catherine Aude-Garcia (LCBM - UMR 5249), Daniel Hanau, Fabienne Proamer, H\\'el\\`ene Diemer (LSMBO-DSA-IPHC), Jean-Marc Strub (LSMBO-DSA-IPHC), Lucie Armand (INAC), Marie Carri\\`ere (INAC), Nathalie Herlin (LFP - URA 2453), Sarah Triboulet (LCBM - UMR 5249), Thierry Rabilloud (LCBM - UMR 5249), V\\'eronique Collin-Faure (LCBM - UMR 5249)","submitted_at":"2014-07-10T09:14:09Z","abstract_excerpt":"Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results are cross-validated by targeted studies. Furthermore, the alteration of important macrophage functions (e.g. phagocytosis) by zinc is also investigated. The intracellular dissolution/uptake of zinc is also studied to further characterize zinc toxicity. Zinc oxide nanoparticles dissolve readily in the cells, leading to high intracellular zinc c"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1407.2732","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}