{"paper":{"title":"Information geometry of chemical reaction networks: Cramer-Rao bound and absolute sensitivity revisited","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["math.DG","math.DS","physics.bio-ph","physics.class-ph"],"primary_cat":"q-bio.MN","authors_text":"Dimitri Loutchko, Tetsuya J. Kobayashi, Yuki Sughiyama","submitted_at":"2025-03-25T06:29:29Z","abstract_excerpt":"Information geometry is based on classical Legendre duality but allows to incorporate additional structure such as algebraic constraints and Bregman divergence functions. It is naturally suited, and has been successfully used, to describe the thermodynamics of chemical reaction networks (CRNs) based on the Legendre duality between concentration and potential spaces, where algebraic constraints are enforced by the stoichiometry. In this article, the Riemannian geometrical aspects of the theory are explored. It is shown that duality between concentration and potential spaces and the natural para"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2503.19384","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2503.19384/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}