{"paper":{"title":"DNA condensation and redissolution: Interaction between overcharged DNA molecules","license":"","headline":"Overcharged DNA molecules interact via a double-minimum force that produces condensation, redissolution, and an intermediate mesocrystal.","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"E.Allahyarov, G.Gompper, H.L\\\"owen","submitted_at":"2004-12-21T00:52:46Z","abstract_excerpt":"The effective DNA-DNA interaction force is calculated by computer simulations with explicit tetravalent counterions and monovalent salt. For overcharged DNA molecules, the interaction force shows a double-minimum structure. The positions and depths of these minima are regulated by the counterion density in the bulk. Using two-dimensional lattice sum and free energy perturbation theories, the coexisting phases for DNA bundles are calculated. A DNA-condensation and redissolution transition and a stable mesocrystal with an intermediate lattice constant for high counterion concentration are obtain"},"claims":{"count":4,"items":[{"kind":"strongest_claim","text":"For overcharged DNA molecules, the interaction force shows a double-minimum structure... A DNA-condensation and redissolution transition and a stable mesocrystal with an intermediate lattice constant for high counterion concentration are obtained.","source":"verdict.strongest_claim","status":"machine_extracted","claim_id":"C1","attestation":"unclaimed"},{"kind":"weakest_assumption","text":"The effective force extracted from two-molecule simulations remains quantitatively valid when many DNA molecules pack together at finite density.","source":"verdict.weakest_assumption","status":"machine_extracted","claim_id":"C2","attestation":"unclaimed"},{"kind":"one_line_summary","text":"Simulations reveal a double-minimum DNA-DNA force that drives condensation-redissolution transitions and a stable mesocrystal at high counterion concentration.","source":"verdict.one_line_summary","status":"machine_extracted","claim_id":"C3","attestation":"unclaimed"},{"kind":"headline","text":"Overcharged DNA molecules interact via a double-minimum force that produces condensation, redissolution, and an intermediate mesocrystal.","source":"verdict.pith_extraction.headline","status":"machine_extracted","claim_id":"C4","attestation":"unclaimed"}],"snapshot_sha256":"4f11ea80bdaedc6967adf582d956496e2228cc11570b4685925bbcfc63326959"},"source":{"id":"q-bio/0412039","kind":"arxiv","version":2},"verdict":{"id":"66842162-17e3-4c1b-ae2d-1ffdaf852a6e","model_set":{"reader":"grok-4.3"},"created_at":"2026-05-14T22:12:54.004866Z","strongest_claim":"For overcharged DNA molecules, the interaction force shows a double-minimum structure... A DNA-condensation and redissolution transition and a stable mesocrystal with an intermediate lattice constant for high counterion concentration are obtained.","one_line_summary":"Simulations reveal a double-minimum DNA-DNA force that drives condensation-redissolution transitions and a stable mesocrystal at high counterion concentration.","pipeline_version":"pith-pipeline@v0.9.0","weakest_assumption":"The effective force extracted from two-molecule simulations remains quantitatively valid when many DNA molecules pack together at finite density.","pith_extraction_headline":"Overcharged DNA molecules interact via a double-minimum force that produces condensation, redissolution, and an intermediate mesocrystal."},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/q-bio/0412039/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":1,"snapshot_sha256":"dbed516100be7e26ecefd92c2e3fe6e61bd0ba489b2cb8ed5f6826711159041d"},"author_claims":{"count":1,"strong_count":1,"snapshot_sha256":"5e3b23b793a24ad44d50f012bed3c12f7c9e9c566d826ad85b79440943422c6c"},"builder_version":"pith-number-builder-2026-05-17-v1"}