{"paper":{"title":"Frequentist-calibrated Bayesian group sequential design with dynamic borrowing","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Francesco Mariani, Fulvio De Santis, Shirin Golchi, Stefania Gubbiotti","submitted_at":"2026-07-31T07:37:12Z","abstract_excerpt":"Bayesian analysis is increasingly used in clinical trials. However, assessment of the design with respect to the frequentist operating characteristics, such as type I error and power, remains a regulatory requirement in many cases. It is well established that, when information is borrowed from external sources to the trial, imposing strict frequentist type I error rate control is equivalent to offsetting the borrowing, which results in no power gains. We propose a Bayesian group sequential design with dynamic borrowing that exploits an explicit correspondence between Bayesian decision criteria"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.29108","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.29108/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}