{"paper":{"title":"Feedback-mediated circulation and persistence of stochastic fluctuations in gene regulatory circuits","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"physics.bio-ph","authors_text":"Mintu Nandi, Nashita Rahman, Sudip Chattopadhyay, Suman K Banik","submitted_at":"2026-07-20T09:39:05Z","abstract_excerpt":"Feedback plays a significant role in biochemical networks that govern a multitude of cellular functions, including development, adaptation, and homeostasis. Yet, how feedback topology controls stochastic fluctuations remains incompletely understood. Here, we develop a theoretical framework for two-node feedback motifs composed of activating and repressive regulatory interactions between two transcription factors. Under the linear noise approximation, we identify a feedback-driven contribution to node-wise fluctuations, termed cyclic noise, that arises specifically from loop closure. Cyclic noi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.17743","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.17743/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}