{"paper":{"title":"Multiscale order, flocking and phenotypic hysteresis in the cellular Potts model of epithelia","license":"http://creativecommons.org/licenses/by/4.0/","headline":"In the cellular Potts model of epithelia, increasing actin polymerization rate drives a transition to long-range flocking with multiscale orientational order and phenotypic hysteresis.","cross_cats":["physics.bio-ph"],"primary_cat":"cond-mat.soft","authors_text":"Calvin C. Bakker, Fran\\c{c}ois Graner, Luca Giomi, Marc Durand","submitted_at":"2026-05-14T17:52:19Z","abstract_excerpt":"In epithelia, how do collective cell migration and tissue spatial organization feedback on each other? We address this question through large-scale numerical simulations of the cellular Potts model. By accounting for both cell morphology and cytoskeletal activity, we uncover a remarkably rich phase diagram featuring multiple types of orientational order, either as distinct phases or coexisting across length scales. We identify a specific pathway in parameter space along which a gradual increase in the actin polymerization rate drives a phase transition into a long-range flocking state. Simulta"},"claims":{"count":4,"items":[{"kind":"strongest_claim","text":"We uncover a remarkably rich phase diagram featuring multiple types of orientational order, either as distinct phases or coexisting across length scales. We identify a specific pathway in parameter space along which a gradual increase in the actin polymerization rate drives a phase transition into a long-range flocking state.","source":"verdict.strongest_claim","status":"machine_extracted","claim_id":"C1","attestation":"unclaimed"},{"kind":"weakest_assumption","text":"That the specific implementation of cytoskeletal activity and cell morphology in the cellular Potts model sufficiently captures the essential physics of real epithelial cell monolayers to produce the observed orders and hysteresis.","source":"verdict.weakest_assumption","status":"machine_extracted","claim_id":"C2","attestation":"unclaimed"},{"kind":"one_line_summary","text":"Cellular Potts model simulations uncover multiscale orientational order, actin-driven flocking transitions, and phenotypic hysteresis in epithelial monolayers.","source":"verdict.one_line_summary","status":"machine_extracted","claim_id":"C3","attestation":"unclaimed"},{"kind":"headline","text":"In the cellular Potts model of epithelia, increasing actin polymerization rate drives a transition to long-range flocking with multiscale orientational order and phenotypic hysteresis.","source":"verdict.pith_extraction.headline","status":"machine_extracted","claim_id":"C4","attestation":"unclaimed"}],"snapshot_sha256":"90043d0b247b35336d5e23ba05f4c4bc24030cdc261b4534c5b515ff857a8e94"},"source":{"id":"2605.15159","kind":"arxiv","version":1},"verdict":{"id":"1885bb5e-c434-4daf-b234-fbb59b3ade86","model_set":{"reader":"grok-4.3"},"created_at":"2026-05-15T03:08:17.038334Z","strongest_claim":"We uncover a remarkably rich phase diagram featuring multiple types of orientational order, either as distinct phases or coexisting across length scales. We identify a specific pathway in parameter space along which a gradual increase in the actin polymerization rate drives a phase transition into a long-range flocking state.","one_line_summary":"Cellular Potts model simulations uncover multiscale orientational order, actin-driven flocking transitions, and phenotypic hysteresis in epithelial monolayers.","pipeline_version":"pith-pipeline@v0.9.0","weakest_assumption":"That the specific implementation of cytoskeletal activity and cell morphology in the cellular Potts model sufficiently captures the essential physics of real epithelial cell monolayers to produce the observed orders and hysteresis.","pith_extraction_headline":"In the cellular Potts model of epithelia, increasing actin polymerization rate drives a transition to long-range flocking with multiscale orientational order and phenotypic hysteresis."},"references":{"count":57,"sample":[{"doi":"","year":2023,"title":"J.-M. Armengol-Collado, L. N. Carenza, J. Eckert, D. Krommydas, and L. Giomi, Nat. Phys.19, 1773 (2023)","work_id":"03671270-11ce-4e50-991f-861b9bf4a979","ref_index":1,"cited_arxiv_id":"","is_internal_anchor":false},{"doi":"","year":2023,"title":"J. Eckert, B. Ladoux, R.-M. M` ege, L. Giomi, and T. Schmidt, Nature Communications14, 5762 (2023)","work_id":"36ca99aa-8467-4b3c-8a3c-a7e6d843006b","ref_index":2,"cited_arxiv_id":"","is_internal_anchor":false},{"doi":"","year":2024,"title":"J.-M. Armengol-Collado, L. N. Nicola, and L. Giomi, eLife13, e86400 (2024)","work_id":"41f8369a-72c0-42c8-88c7-d53601ccda21","ref_index":3,"cited_arxiv_id":"","is_internal_anchor":false},{"doi":"","year":2025,"title":"L. N. Carenza, J.-M. Armengol-Collado, D. Krommydas, and L. Giomi, Phys. Rev. Lett.134, 128304 (2025)","work_id":"d1855e40-453d-49f4-8f73-4379b73b4d01","ref_index":4,"cited_arxiv_id":"","is_internal_anchor":false},{"doi":"","year":2018,"title":"Y.-W. Li and M. Pica Ciamarra, Phys. Rev. Mater.2, 045602 (2018)","work_id":"6b675ec8-7208-4084-a1f1-c722d7c26efb","ref_index":5,"cited_arxiv_id":"","is_internal_anchor":false}],"resolved_work":57,"snapshot_sha256":"797b9d0e14a8bdf2dcc59af7d3f1f5f58c64e572f6a2812895694bf74b1c6e03","internal_anchors":2},"formal_canon":{"evidence_count":2,"snapshot_sha256":"4aedc13a711849a6e553e8a5f926422c87500b44e91d0455dbe85cf8398f7c87"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}