{"paper":{"title":"Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Alessandro Sette, Amanda Wriston, A. Michelle English, Andrew Lucas, Barry J. Grant, Bjoern Peters, Carla Oseroff, Cesar Augusto. F. de Oliveira, David A. Ostrov, Donald F. Hunt, Elizabeth Phillips, Howard Grey, Hu Mei, Jean Jakoncic, Jeffrey Shabanowitz, John Sidney, Leming Shi, Lun Yang, Mikkel Harndahl, Scott Southwood, Shun Lu, Simon Mallal, Soren Buus, Yuri A. Pompeu","submitted_at":"2012-05-21T21:51:08Z","abstract_excerpt":"Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkage between drug hypersensitivity reactions to several drugs and specific HLA alleles. One of the strongest such genetic associations found has been for the antiviral drug abacavir, which causes severe adverse reactions exclusively in patients expressing the HLA mole"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1205.4759","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}