{"paper":{"title":"Stochastic Modeling and Statistical Inference of Intrinsic Noise in Gene Regulation System via Chemical Master Equation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN","q-bio.QM"],"primary_cat":"stat.ME","authors_text":"Chao Du, Wing Hong Wong","submitted_at":"2016-10-23T18:39:42Z","abstract_excerpt":"Intrinsic noise, the stochastic cell-to-cell fluctuations in mRNAs and proteins, has been observed and proved to play important roles in cellular systems. Due to the recent development in single-cell-level measurement technology, the studies on intrinsic noise are becoming increasingly popular among scholars. The chemical master equation (CME) has been used to model the evolutions of complex chemical and biological systems since 1940, and are often served as the standard tool for modeling intrinsic noise in gene regulation system. A CME-based model can capture the discrete, stochastic, and dyn"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.07213","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}