{"paper":{"title":"Methods for scoring the collective effect of SNPs: Minor alleles of common SNPs quantitatively affect traits/diseases and are under both positive and negative selection","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE"],"primary_cat":"q-bio.GN","authors_text":"Amanda D. Rice, Ayca Dogan, Ceng Zeng, Dapeng Wang, Dejian Yuan, Eva Medina, Gudrun Brockmann, Hui Guo, Jiegen Zhang, Jie Liang, Jun Chen, Jun Yu, Ke Yi, Kun Xia, Long Ma, Oliver Goldmann, Qing Lu, Richard W. Moyer, Shi Huang, Xian Man, Xiaohua Tan, Yanke Li, Yimin Huang, Zuobin Zhu","submitted_at":"2012-09-12T06:30:22Z","abstract_excerpt":"Most common SNPs are popularly assumed to be neutral. We here developed novel methods to examine in animal models and humans whether extreme amount of minor alleles (MAs) carried by an individual may represent extreme trait values and common diseases. We analyzed panels of genetic reference populations and identified the MAs in each panel and the MA content (MAC) that each strain carried. We also analyzed 21 published GWAS datasets of human diseases and identified the MAC of each case or control. MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms, i"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1209.2911","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}