{"paper":{"title":"Linking GFAP Levels to Speech Anomalies in Acute Brain Injury: A Simulation Based Study","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Bin Hu, Shamaley Aravinthan","submitted_at":"2025-08-13T18:49:11Z","abstract_excerpt":"Background: Glial fibrillary acidic protein (GFAP) is a biomarker for intracerebral hemorrhage and traumatic brain injury, but its link to acute speech disruption is untested. Speech anomalies often emerge early after injury, enabling rapid triage.\n  Methods: We simulated a cohort of 200 virtual patients stratified by lesion location, onset time, and severity. GFAP kinetics followed published trajectories; speech anomalies were generated from lesion-specific neurophysiological mappings. Ensemble machine-learning models used GFAP, speech, and lesion features; robustness was tested under noise, "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.10130","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.10130/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}