{"paper":{"title":"Effects of Local Concentration Gradients of Monocyte Chemoattractant Protein-1 (MCP-1) on Monocytes Adhesion and Transendothelial Migration in a Three-Dimensional (3D) In Vitro Vascular Tissue Model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Heather Gappa-Fahlenkamp, Mohamad Eftekharjoo, Neda Ghousifam, Tahereh Derakhshan","submitted_at":"2019-03-12T18:50:50Z","abstract_excerpt":"Objective: The main objective of this study was to investigate the formation of MCP-1 concentration gradients within the subendothelial ECM and determine the effect on monocytes migration in response to inflammation. To meet this objective, monocytes migration in a 3D vascular tissue model, containing a matrix where concentration gradients may form, was compared to that in a 2D cell culture model results.\n  Materials: The 3D vascular tissue model consists of human aortic endothelial cells (HAEC) grown on the surface of a collagen matrix. The HAEC form an endothelium and the collagen is used to"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.05144","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}