{"paper":{"title":"Differentiable Cardiac Electrophysiology Simulations for Dynamical State and Parameter Estimation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["nlin.CD","physics.bio-ph"],"primary_cat":"physics.med-ph","authors_text":"Adarsh Pashikanti, Alex Ho, Emilia Entcheva, Jan Christoph, Shrey Chowdhary, Weizhen Li","submitted_at":"2026-07-16T22:42:48Z","abstract_excerpt":"The heart's contractions are triggered by action potential waves, which propagate through the cardiac muscle and exhibit diverse spatio-temporal dynamics during different heart rhythms. The dynamics are modeled with partial differential equations (PDEs) in cardiac electrophysiology simulations. However, fitting such models to measurement data to develop digital twins or patient-specific computer models is challenging. Here, we introduce differentiable cardiac electrophysiology simulations that can be fitted automatically to spatio-temporal measurement data of action potential waves in cardiac "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.15492","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.15492/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}