{"paper":{"title":"Experimental Validation of Skull Acoustic Modelling Strategies for Transcranial Focused Ultrasound Simulation: A Cross-Comparison Study","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Aidan J Horner, Han Li, Xinyu Zhang, Zhihong Huang","submitted_at":"2026-06-08T13:50:20Z","abstract_excerpt":"Accurate acoustic modelling of the skull is essential for simulation-guided transcranial focused ultrasound (tFUS), but commonly used skull parameterisation strategies differ in complexity and reported accuracy. This study experimentally compared five k-Wave skull models: two voxel-wise linear mapping models, two three-layer models, and one single-layer fixed-parameter model. Nineteen regions of interest from five historical and two Thiel-embalmed human skulls were tested at 220 kHz, 680 kHz, and 1000 kHz. Bowl-surface source fields were reconstructed using acoustic holography, and simulated i"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.09497","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.09497/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}