{"paper":{"title":"Biophysics-based critique of the assisted discharge mechanism hypothesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"James C. Weaver, Julie V. Stern, Kyle C. Smith, Thiruvallur R. Gowrishankar","submitted_at":"2019-04-01T04:36:16Z","abstract_excerpt":"Cell experiments with large, short electric field pulses of opposite polarity reveal a remarkable phenomenon: Bipolar cancellation (BPC). Typical defining experiments involve quantitative observation of tracer molecule influx at times of order 100 s post pulsing. Gowrishankar et al. BBRC 2018 503:1194-1199 shows that long-lived pores and altered partitioning or hindrance due to inserted occluding molecules can account for BPC. In stark contrast, the Assisted Discharge (AD) hypothesis, Pakhomov et al. CellMol- LifeSci 2014 71(22):4431-4441; Fig. 6, only involves early times of a microsecond dow"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.00559","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"}