STOMP extends direct preference optimization to the multi-objective setting via smooth Tchebysheff scalarization and standardization of observed rewards, achieving highest hypervolume in eight of nine protein engineering evaluations.
Aligning protein generative models with experimental fitness via direct preference optimization
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Diversity-regularized DPO fine-tuning of ProteinMPNN improves structural similarity scores by at least 8% over base model and sequence diversity by up to 20% over standard DPO for peptide inverse folding on OpenFold structures.
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Pareto-Optimal Offline Reinforcement Learning via Smooth Tchebysheff Scalarization
STOMP extends direct preference optimization to the multi-objective setting via smooth Tchebysheff scalarization and standardization of observed rewards, achieving highest hypervolume in eight of nine protein engineering evaluations.
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Improving Inverse Folding for Peptide Design with Diversity-regularized Direct Preference Optimization
Diversity-regularized DPO fine-tuning of ProteinMPNN improves structural similarity scores by at least 8% over base model and sequence diversity by up to 20% over standard DPO for peptide inverse folding on OpenFold structures.