The paper reviews four ongoing HIV prevention efficacy trials and discusses statistical considerations for sequel trial designs accounting for evolving interventions, correlates of protection, and low incidence.
Placebo use in vaccine trials: recommendations of a WHO expert panel
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Ongoing Vaccine and Monoclonal Antibody HIV Prevention Efficacy Trials and Considerations for Sequel Efficacy Trial Designs
The paper reviews four ongoing HIV prevention efficacy trials and discusses statistical considerations for sequel trial designs accounting for evolving interventions, correlates of protection, and low incidence.