The paper proposes a two-timescale physical model in which optimal viscoelastic energy transfer sets focal adhesion stiffness, and adhesion growth and shrinkage are described as active wetting and de-wetting modulated by Piezo1 calcium signaling.
Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects
3 Pith papers cite this work, alongside 4 external citations. Polarity classification is still indexing.
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Marangoni-driven flows explain heterogeneous Piezo1 distribution in epithelial cells and higher activity in cancer cells through membrane interactions and driving forces.
Irregular curvature at focal adhesions in cancer cells preserves Piezo1 activity under LIUS while regular curvature in healthy cells reduces it via cholesterol effects, providing a proposed basis for selective apoptosis.
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Marangoni-Driven Redistribution and Activity of Piezo1 Molecules in Epithelial and Cancer Cells
Marangoni-driven flows explain heterogeneous Piezo1 distribution in epithelial cells and higher activity in cancer cells through membrane interactions and driving forces.