DISCO co-designs protein sequence and structure to produce functional heme enzymes that catalyze several new-to-nature carbene-transfer reactions at activities exceeding prior engineered enzymes.
Dauparas,et al., Robust deep learning–based protein sequence design using Protein- MPNN.Science378(6615), 49–56 (2022)
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General Multimodal Protein Design Enables DNA-Encoding of Chemistry
DISCO co-designs protein sequence and structure to produce functional heme enzymes that catalyze several new-to-nature carbene-transfer reactions at activities exceeding prior engineered enzymes.