TGUHm with dual-thresholding achieves higher true positive rates and lower false positive rates than CBS, HaarSeg, and FDRSeg for detecting both short and long copy number alterations under Gaussian and heavy-tailed noise.
Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens
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Tail-Greedy Unbalanced Haar Wavelet Segmentation for Copy Number Alteration Data
TGUHm with dual-thresholding achieves higher true positive rates and lower false positive rates than CBS, HaarSeg, and FDRSeg for detecting both short and long copy number alterations under Gaussian and heavy-tailed noise.