Spontaneous CPT asymmetry of the Universe

The extended QED with renormalizable interactions breaking the Lorentz and CPT symmetry is considered and the phenomenological consequences of such a symmetry breaking are illuminated in view of recent discussion of large scale anisotropy of the Universe. Other physical effects in QED with CPT violation are examined, in particular, mass splitting between electrons of different helicities and decay of very high energetic electrons into lower energy electrons and positrons.