{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2025:25G4IQ54642BZHPZUGFUPDZXDT","short_pith_number":"pith:25G4IQ54","schema_version":"1.0","canonical_sha256":"d74dc443bcf7341c9df9a18b478f371cc1d6baf5acf111130d20613f34a71352","source":{"kind":"arxiv","id":"2505.06447","version":1},"attestation_state":"computed","paper":{"title":"Lipidation-induced bacterial cell membrane translocation of star-peptides","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cond-mat.soft"],"primary_cat":"physics.bio-ph","authors_text":"Amal Jayawardena, Andrew Hung, Elnaz Hajizadeh, Greg Qiao","submitted_at":"2025-05-09T21:30:22Z","abstract_excerpt":"The rapid emergence of multidrug-resistant (MDR) bacteria demands development of novel and effective antimicrobial agents. Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs), characterized by their unique star-shaped architecture and potent multivalent interactions, represent a promising solution. This study leverages molecular dynamics simulations to investigate the impact of lipidation on SNAPPs' structural stability, membrane interactions, and antibacterial efficacy. We show that lipidation with hexanoic acid (C6), lauric acid (C12), and stearic acid (C18) enhances the {\\al"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2505.06447","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-05-09T21:30:22Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"e07ad8f03e5d5036d798b8ce859eca57cec48c52c69d358e646773bb96f83650","abstract_canon_sha256":"07f2cb3d5e27d46f90edeb9c02fe46a1567a43251fc188c6a15b1c091fb8cd62"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:01:09.787273Z","signature_b64":"lD0BIu2/MUEsSigkh76v20r0sLRr5kTec0OyonRrqTnGNnSSWwxN0FWVR7l/btq8qiJjmMkAmRMXQABKqprhAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d74dc443bcf7341c9df9a18b478f371cc1d6baf5acf111130d20613f34a71352","last_reissued_at":"2026-07-05T11:01:09.786813Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:01:09.786813Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Lipidation-induced bacterial cell membrane translocation of star-peptides","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cond-mat.soft"],"primary_cat":"physics.bio-ph","authors_text":"Amal Jayawardena, Andrew Hung, Elnaz Hajizadeh, Greg Qiao","submitted_at":"2025-05-09T21:30:22Z","abstract_excerpt":"The rapid emergence of multidrug-resistant (MDR) bacteria demands development of novel and effective antimicrobial agents. Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs), characterized by their unique star-shaped architecture and potent multivalent interactions, represent a promising solution. This study leverages molecular dynamics simulations to investigate the impact of lipidation on SNAPPs' structural stability, membrane interactions, and antibacterial efficacy. We show that lipidation with hexanoic acid (C6), lauric acid (C12), and stearic acid (C18) enhances the {\\al"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.06447","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.06447/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2505.06447","created_at":"2026-07-05T11:01:09.786869+00:00"},{"alias_kind":"arxiv_version","alias_value":"2505.06447v1","created_at":"2026-07-05T11:01:09.786869+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.06447","created_at":"2026-07-05T11:01:09.786869+00:00"},{"alias_kind":"pith_short_12","alias_value":"25G4IQ54642B","created_at":"2026-07-05T11:01:09.786869+00:00"},{"alias_kind":"pith_short_16","alias_value":"25G4IQ54642BZHPZ","created_at":"2026-07-05T11:01:09.786869+00:00"},{"alias_kind":"pith_short_8","alias_value":"25G4IQ54","created_at":"2026-07-05T11:01:09.786869+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT","json":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT.json","graph_json":"https://pith.science/api/pith-number/25G4IQ54642BZHPZUGFUPDZXDT/graph.json","events_json":"https://pith.science/api/pith-number/25G4IQ54642BZHPZUGFUPDZXDT/events.json","paper":"https://pith.science/paper/25G4IQ54"},"agent_actions":{"view_html":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT","download_json":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT.json","view_paper":"https://pith.science/paper/25G4IQ54","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2505.06447&json=true","fetch_graph":"https://pith.science/api/pith-number/25G4IQ54642BZHPZUGFUPDZXDT/graph.json","fetch_events":"https://pith.science/api/pith-number/25G4IQ54642BZHPZUGFUPDZXDT/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT/action/timestamp_anchor","attest_storage":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT/action/storage_attestation","attest_author":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT/action/author_attestation","sign_citation":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT/action/citation_signature","submit_replication":"https://pith.science/pith/25G4IQ54642BZHPZUGFUPDZXDT/action/replication_record"}},"created_at":"2026-07-05T11:01:09.786869+00:00","updated_at":"2026-07-05T11:01:09.786869+00:00"}