{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:25JKNQSJXJC3IFQAIR5GBQRWLQ","short_pith_number":"pith:25JKNQSJ","canonical_record":{"source":{"id":"2501.02282","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-01-04T13:20:48Z","cross_cats_sorted":[],"title_canon_sha256":"a1303089c2f768e88cada2aded23e4ba608c7f0251e76bd70d535c09c04a2bb1","abstract_canon_sha256":"36ec5750ac973c0dcac8cc9cbc8131bc5e46ee6bea5141915b0837222ff82ed4"},"schema_version":"1.0"},"canonical_sha256":"d752a6c249ba45b41600447a60c2365c06003b0439bbb84df81d5162f9a5f836","source":{"kind":"arxiv","id":"2501.02282","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2501.02282","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"arxiv_version","alias_value":"2501.02282v1","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2501.02282","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"pith_short_12","alias_value":"25JKNQSJXJC3","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"pith_short_16","alias_value":"25JKNQSJXJC3IFQA","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"pith_short_8","alias_value":"25JKNQSJ","created_at":"2026-07-05T09:57:05Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:25JKNQSJXJC3IFQAIR5GBQRWLQ","target":"record","payload":{"canonical_record":{"source":{"id":"2501.02282","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-01-04T13:20:48Z","cross_cats_sorted":[],"title_canon_sha256":"a1303089c2f768e88cada2aded23e4ba608c7f0251e76bd70d535c09c04a2bb1","abstract_canon_sha256":"36ec5750ac973c0dcac8cc9cbc8131bc5e46ee6bea5141915b0837222ff82ed4"},"schema_version":"1.0"},"canonical_sha256":"d752a6c249ba45b41600447a60c2365c06003b0439bbb84df81d5162f9a5f836","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:57:05.315954Z","signature_b64":"uxIGjwMUd1UTE4i1ifAALtry5T9Uus9bQ8ZnL52qISPy5iVZnJGUCp8u//qH1bJ3iCk6Ob3RQdh1/jNPmzLrAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d752a6c249ba45b41600447a60c2365c06003b0439bbb84df81d5162f9a5f836","last_reissued_at":"2026-07-05T09:57:05.315499Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:57:05.315499Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2501.02282","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:57:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"e4p1WyIPspr9N/vXp5EDIk2FzbrAwmseUxyBPocrxrIrDvXmQoHnWjnjgisIVBxO3H2b8CxuyTqcxlB62mBIDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T16:02:04.478853Z"},"content_sha256":"8464d8eded1fd074464d9fe9e2c10c24281d72d6284ba427fd247a6db1161126","schema_version":"1.0","event_id":"sha256:8464d8eded1fd074464d9fe9e2c10c24281d72d6284ba427fd247a6db1161126"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:25JKNQSJXJC3IFQAIR5GBQRWLQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Progress of the anti-obesity of Berberine","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Kong Yue, Nian Xin, Nie Rong, Yang haokun, Zhang Hongtao, Zhang Xuxiang","submitted_at":"2025-01-04T13:20:48Z","abstract_excerpt":"Obesity is defined as the excessive accumulation or abnormal distribution of body fat. According to data from World Obesity Atlas 2024, the increase in prevalence of obesity has become a major worldwide health problem in adults as well as among children and adolescents. Although an increasing number of drugs have been approved for the treatment of obesity in recent years, many of these drugs have inevitable side effects which have increased the demand for new safe, accessible and effective drugs for obesity and prompt interest in natural products. Berberine (BBR) and its metabolites, known for"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2501.02282","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2501.02282/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:57:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3g2MDUkUlrJ/I7hZf6R6X+yg/upSoTvZnXnEG8rtObKeqWv+UexQaoz3PPawQY7qnMpAGkN08Cu7CECWzSJDDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T16:02:04.479199Z"},"content_sha256":"4d4c775114c6001bde16026438878d9e3b20defc3ee6cb7efe7071098036257f","schema_version":"1.0","event_id":"sha256:4d4c775114c6001bde16026438878d9e3b20defc3ee6cb7efe7071098036257f"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ/bundle.json","state_url":"https://pith.science/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-14T16:02:04Z","links":{"resolver":"https://pith.science/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ","bundle":"https://pith.science/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ/bundle.json","state":"https://pith.science/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/25JKNQSJXJC3IFQAIR5GBQRWLQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:25JKNQSJXJC3IFQAIR5GBQRWLQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"36ec5750ac973c0dcac8cc9cbc8131bc5e46ee6bea5141915b0837222ff82ed4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-01-04T13:20:48Z","title_canon_sha256":"a1303089c2f768e88cada2aded23e4ba608c7f0251e76bd70d535c09c04a2bb1"},"schema_version":"1.0","source":{"id":"2501.02282","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2501.02282","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"arxiv_version","alias_value":"2501.02282v1","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2501.02282","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"pith_short_12","alias_value":"25JKNQSJXJC3","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"pith_short_16","alias_value":"25JKNQSJXJC3IFQA","created_at":"2026-07-05T09:57:05Z"},{"alias_kind":"pith_short_8","alias_value":"25JKNQSJ","created_at":"2026-07-05T09:57:05Z"}],"graph_snapshots":[{"event_id":"sha256:4d4c775114c6001bde16026438878d9e3b20defc3ee6cb7efe7071098036257f","target":"graph","created_at":"2026-07-05T09:57:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2501.02282/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Obesity is defined as the excessive accumulation or abnormal distribution of body fat. According to data from World Obesity Atlas 2024, the increase in prevalence of obesity has become a major worldwide health problem in adults as well as among children and adolescents. Although an increasing number of drugs have been approved for the treatment of obesity in recent years, many of these drugs have inevitable side effects which have increased the demand for new safe, accessible and effective drugs for obesity and prompt interest in natural products. Berberine (BBR) and its metabolites, known for","authors_text":"Kong Yue, Nian Xin, Nie Rong, Yang haokun, Zhang Hongtao, Zhang Xuxiang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-01-04T13:20:48Z","title":"Progress of the anti-obesity of Berberine"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2501.02282","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8464d8eded1fd074464d9fe9e2c10c24281d72d6284ba427fd247a6db1161126","target":"record","created_at":"2026-07-05T09:57:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"36ec5750ac973c0dcac8cc9cbc8131bc5e46ee6bea5141915b0837222ff82ed4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-01-04T13:20:48Z","title_canon_sha256":"a1303089c2f768e88cada2aded23e4ba608c7f0251e76bd70d535c09c04a2bb1"},"schema_version":"1.0","source":{"id":"2501.02282","kind":"arxiv","version":1}},"canonical_sha256":"d752a6c249ba45b41600447a60c2365c06003b0439bbb84df81d5162f9a5f836","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d752a6c249ba45b41600447a60c2365c06003b0439bbb84df81d5162f9a5f836","first_computed_at":"2026-07-05T09:57:05.315499Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:57:05.315499Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"uxIGjwMUd1UTE4i1ifAALtry5T9Uus9bQ8ZnL52qISPy5iVZnJGUCp8u//qH1bJ3iCk6Ob3RQdh1/jNPmzLrAg==","signature_status":"signed_v1","signed_at":"2026-07-05T09:57:05.315954Z","signed_message":"canonical_sha256_bytes"},"source_id":"2501.02282","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8464d8eded1fd074464d9fe9e2c10c24281d72d6284ba427fd247a6db1161126","sha256:4d4c775114c6001bde16026438878d9e3b20defc3ee6cb7efe7071098036257f"],"state_sha256":"adf766cec7a9b615a6ae4f8d3f3768b75f9866561bbffb32db3ed5d70971f7ec"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"V+HFbTo/LkEh9/9YQWTwJ8hix3gf+1C5ItrxJCSZW1Oi6uqnQnZsnJjtkERqv6HkNdg/DM6ni7hTMGhp4tDVBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-14T16:02:04.482818Z","bundle_sha256":"dfd2e3a46de86189dd45f3b05d75ee271c2f06fc8e0d22e1020f6aa5f5413fce"}}