{"schema":"https://pith.science/schemas/pith-integrity/v1.json","pith_number":"2607.15101","arxiv_id":"2607.15101","integrity":{"available":true,"endpoint":"/pith/2607.15101/integrity.json","summary":{"critical":0,"advisory":3,"informational":0,"by_detector":{"doi_compliance":{"total":3,"critical":0,"advisory":3,"informational":0}}},"clean":false,"detectors_run":[{"name":"doi_compliance","version":"1.1.0","status":"completed","ran_at":"2026-08-03T00:30:51.383273Z","findings_count":3},{"name":"doi_title_agreement","version":"1.0.0","status":"completed","ran_at":"2026-08-02T03:38:51.153380Z","findings_count":0},{"name":"ai_meta_artifact","version":"1.0.0","status":"skipped","ran_at":"2026-07-31T08:51:53.934833Z","findings_count":0},{"name":"cited_work_retraction","version":"1.0.0","status":"completed","ran_at":"2026-07-24T21:53:05.677232Z","findings_count":0},{"name":"claim_evidence","version":"1.0.0","status":"completed","ran_at":"2026-07-23T13:29:38.540236Z","findings_count":0},{"name":"external_links","version":"1.0.0","status":"completed","ran_at":"2026-07-19T23:34:19.600524Z","findings_count":0},{"name":"citation_quote_validity","version":"0.1.0","status":"skipped","ran_at":"2026-07-19T05:57:10.795359Z","findings_count":0},{"name":"shingle_duplication","version":"0.1.0","status":"skipped","ran_at":"2026-07-17T13:53:42.091385Z","findings_count":0}],"findings":[{"detector":"doi_compliance","finding_type":"recoverable_identifier","severity":"advisory","verdict_class":"incontrovertible","note":"DOI is split by whitespace or line breaks in the printed bibliography. Reconstructed DOI 10.1073/pnas.1424461112 resolves to 'Kinetics of protein–ligand unbinding: Predicting pathways, rates, and rate-limiting steps'. A reader following the printed text alone cannot reach it.","detected_doi":"10.1073/pnas.1424461112","detected_arxiv_id":null,"ref_index":9,"audited_at":"2026-08-02T00:20:27.628086Z"},{"detector":"doi_compliance","finding_type":"recoverable_identifier","severity":"advisory","verdict_class":"incontrovertible","note":"DOI is split by whitespace or line breaks in the printed bibliography. Reconstructed DOI 10.1021/acs.jcim.7b00564 resolves to 'Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations'. A reader following the printed text alone cannot reach it.","detected_doi":"10.1021/acs.jcim.7b00564","detected_arxiv_id":null,"ref_index":2,"audited_at":"2026-08-02T00:20:27.628086Z"},{"detector":"doi_compliance","finding_type":"recoverable_identifier","severity":"advisory","verdict_class":"incontrovertible","note":"DOI is split by whitespace or line breaks in the printed bibliography. Reconstructed DOI 10.1103/PhysRevLett.111.230602 resolves to 'From Metadynamics to Dynamics'. A reader following the printed text alone cannot reach it.","detected_doi":"10.1103/PhysRevLett.111.230602","detected_arxiv_id":null,"ref_index":8,"audited_at":"2026-08-02T00:20:27.628086Z"}],"snapshot_sha256":"bd7d2f190006170c00bd60e75caf7bec7bea0ce05742bfedfbee3a83a180f017"},"events":[{"event_id":16900,"event_type":"pith.integrity.v1","payload_sha256":"b284eb5d7fda827bf7b7657173fadd4b091dc266632363267ccb2dd91ce90abb","signature_b64":"R0tG8ZQdZpOXy9AqKuNNg5LNjZXZf8k/zRI3poGWydENvK55+guQAkatTuTgmuykLncR5JUHNfgSsr2yjzdmCw==","signing_key_id":"pith-v1-2026-05","created_at":"2026-08-02T00:23:31.271498+00:00","payload":{"note":"DOI is split by whitespace or line breaks in the printed bibliography. Reconstructed DOI 10.1073/pnas.1424461112 resolves to 'Kinetics of protein–ligand unbinding: Predicting pathways, rates, and rate-limiting steps'. A reader following the printed text alone cannot reach it.","snippet":"Tiwary, P., Limongelli, V., Salvalaglio, M., Parrinello, M.: Kinetics of protein– ligand unbinding: Predicting pathways, rates, and rate-limiting steps. Proceedings of the National Academy of Sciences112(5) (2015) https://doi.org/10.1073/pn","arxiv_id":"2607.15101","detector":"doi_compliance","evidence":{"ref_index":9,"verdict_class":"incontrovertible","resolved_title":"Kinetics of protein–ligand unbinding: Predicting pathways, rates, and rate-limiting steps","printed_excerpt":"10.1073/pnas","reconstructed_doi":"10.1073/pnas.1424461112"},"severity":"advisory","ref_index":9,"audited_at":"2026-08-02T00:20:27.628086Z","event_type":"pith.integrity.v1","detected_doi":"10.1073/pnas.1424461112","detector_url":"https://pith.science/pith-integrity-protocol#doi_compliance","external_url":null,"finding_type":"recoverable_identifier","evidence_hash":"2abd53b6142134d0ccf7682202af2704bc6583257eb89586bbe72d74c0e9ffe2","paper_version":1,"verdict_class":"incontrovertible","resolved_title":"Kinetics of protein–ligand unbinding: Predicting pathways, rates, and rate-limiting steps","detector_version":"1.1.0","detected_arxiv_id":null}},{"event_id":16899,"event_type":"pith.integrity.v1","payload_sha256":"ce65c0ae36624601ba8548fa068be1937aef76e8737cfdad82268a0d188d442a","signature_b64":"SkN0PJ11QIR33hWVFelc5wT8orMEZZ+G5xH/2j+xP1qV6DVJEyxAJPHYjJx6/NxQ+YCGlkr1ejAYmW2BtdbqBg==","signing_key_id":"pith-v1-2026-05","created_at":"2026-08-02T00:23:30.749738+00:00","payload":{"note":"DOI is split by whitespace or line breaks in the printed bibliography. Reconstructed DOI 10.1103/PhysRevLett.111.230602 resolves to 'From Metadynamics to Dynamics'. A reader following the printed text alone cannot reach it.","snippet":"Tiwary, P., Parrinello, M.: From Metadynamics to Dynamics. Physical Review Letters111(23), 230602 (2013) https://doi.org/10.1103/PhysRevLett. 111.230602","arxiv_id":"2607.15101","detector":"doi_compliance","evidence":{"ref_index":8,"verdict_class":"incontrovertible","resolved_title":"From Metadynamics to Dynamics","printed_excerpt":"10.1103/physrevlett","reconstructed_doi":"10.1103/PhysRevLett.111.230602"},"severity":"advisory","ref_index":8,"audited_at":"2026-08-02T00:20:27.628086Z","event_type":"pith.integrity.v1","detected_doi":"10.1103/PhysRevLett.111.230602","detector_url":"https://pith.science/pith-integrity-protocol#doi_compliance","external_url":null,"finding_type":"recoverable_identifier","evidence_hash":"fbaccc06d34745752c352af2fcded7651d6360534fd3823bbb4aea3f13f2268d","paper_version":1,"verdict_class":"incontrovertible","resolved_title":"From Metadynamics to Dynamics","detector_version":"1.1.0","detected_arxiv_id":null}},{"event_id":16898,"event_type":"pith.integrity.v1","payload_sha256":"72f774c827b09d5eb59a4dfb86aee4ee5f90bde5171a065f2ddc7993f50350a3","signature_b64":"xqmNig23G7AqQEPoHNqS+2DueRymzXClAAnYqK8GN/tS2SpKn4u/nAqIBNU1GXMw4ccW3ay1h+Tc2tcXrVW6CQ==","signing_key_id":"pith-v1-2026-05","created_at":"2026-08-02T00:23:30.449743+00:00","payload":{"note":"DOI is split by whitespace or line breaks in the printed bibliography. Reconstructed DOI 10.1021/acs.jcim.7b00564 resolves to 'Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations'. A reader following the printed text alone cannot reach it.","snippet":"Cournia, Z., Allen, B., Sherman, W.: Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations. Journal of Chemical Information and Modeling57(12) (2017) https://doi.org/10.1021/acs. jcim.7b00","arxiv_id":"2607.15101","detector":"doi_compliance","evidence":{"ref_index":2,"verdict_class":"incontrovertible","resolved_title":"Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations","printed_excerpt":"10.1021/acs","reconstructed_doi":"10.1021/acs.jcim.7b00564"},"severity":"advisory","ref_index":2,"audited_at":"2026-08-02T00:20:27.628086Z","event_type":"pith.integrity.v1","detected_doi":"10.1021/acs.jcim.7b00564","detector_url":"https://pith.science/pith-integrity-protocol#doi_compliance","external_url":null,"finding_type":"recoverable_identifier","evidence_hash":"35a8968954e2626d4d073c413318d09305dca34d23d6752f3c98ef94f0841bcb","paper_version":1,"verdict_class":"incontrovertible","resolved_title":"Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations","detector_version":"1.1.0","detected_arxiv_id":null}}],"endpoint_self":"/pith/2607.15101/integrity.json","protocol_url":"https://pith.science/pith-integrity-protocol"}