{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:2AGD67LTQY7NN3KFU5HIZKLWF2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f17d4e35fd8f2189ca008c15844dce91d711c8a10dd98e2e7ca85449e046243f","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2011-04-12T13:16:09Z","title_canon_sha256":"fdfe57891419d1dc589b3ffd3bf02adb7056ae11c5d8ddea2afded620a11dd01"},"schema_version":"1.0","source":{"id":"1104.2204","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1104.2204","created_at":"2026-05-18T02:02:34Z"},{"alias_kind":"arxiv_version","alias_value":"1104.2204v1","created_at":"2026-05-18T02:02:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1104.2204","created_at":"2026-05-18T02:02:34Z"},{"alias_kind":"pith_short_12","alias_value":"2AGD67LTQY7N","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_16","alias_value":"2AGD67LTQY7NN3KF","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_8","alias_value":"2AGD67LT","created_at":"2026-05-18T12:26:18Z"}],"graph_snapshots":[{"event_id":"sha256:fb3310e991d2325fee53a5c64c7a2ed4ef66299c8a53a7bd1f04dbde7e85fe46","target":"graph","created_at":"2026-05-18T02:02:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"To ensure fast gene activation, Transcription Factors (TF) use a mechanism known as facilitated diffusion to find their DNA promoter site. Here we analyze such a process where a TF alternates between 3D and 1D diffusion. In the latter (TF bound to the DNA), the TF further switches between a fast translocation state dominated by interaction with the DNA backbone, and a slow examination state where interaction with DNA base pairs is predominant. We derive a new formula for the mean search time, and show that it is faster and less sensitive to the binding energy fluctuations compared to the case ","authors_text":"David Holcman, Juergen Reingruber","cross_cats":["q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2011-04-12T13:16:09Z","title":"Transcription factor search for a DNA promoter in a three-states model"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1104.2204","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0a42ce61452391203fb26111eac42386dbdbc0ce192a42419433d00c40739324","target":"record","created_at":"2026-05-18T02:02:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f17d4e35fd8f2189ca008c15844dce91d711c8a10dd98e2e7ca85449e046243f","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2011-04-12T13:16:09Z","title_canon_sha256":"fdfe57891419d1dc589b3ffd3bf02adb7056ae11c5d8ddea2afded620a11dd01"},"schema_version":"1.0","source":{"id":"1104.2204","kind":"arxiv","version":1}},"canonical_sha256":"d00c3f7d73863ed6ed45a74e8ca9762e90e9a0c97f6d8d216e426ed5ded15206","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d00c3f7d73863ed6ed45a74e8ca9762e90e9a0c97f6d8d216e426ed5ded15206","first_computed_at":"2026-05-18T02:02:34.782043Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:02:34.782043Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ZlhMSa0Wl0zrGgwNqnbjFuBU3ttKUizEa5b5G1KBLIFwilrdAK7GRzPhJFXdv4yyvwpDe+HS1KOMDWdrzGHjBA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:02:34.782862Z","signed_message":"canonical_sha256_bytes"},"source_id":"1104.2204","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0a42ce61452391203fb26111eac42386dbdbc0ce192a42419433d00c40739324","sha256:fb3310e991d2325fee53a5c64c7a2ed4ef66299c8a53a7bd1f04dbde7e85fe46"],"state_sha256":"36f15ddbcc7dc8f2f323aeedf42fc167e0f5fee05d04093258ed35967fe16b30"}