{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:2CI2ABDKJCCMTSSYHMO6XMPB6O","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1394bd6cc2da2945be12b0a8c8ecb4d7c4bfd6abeb56a6a4a35aa3890a7e6b15","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2011-01-21T22:57:52Z","title_canon_sha256":"1fc7c615384abc4e8fe0cd6fc356ccd8d8ee6207199dae31f30cfb0e42f1a6fc"},"schema_version":"1.0","source":{"id":"1101.4242","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1101.4242","created_at":"2026-05-18T02:22:50Z"},{"alias_kind":"arxiv_version","alias_value":"1101.4242v1","created_at":"2026-05-18T02:22:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1101.4242","created_at":"2026-05-18T02:22:50Z"},{"alias_kind":"pith_short_12","alias_value":"2CI2ABDKJCCM","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_16","alias_value":"2CI2ABDKJCCMTSSY","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_8","alias_value":"2CI2ABDK","created_at":"2026-05-18T12:26:18Z"}],"graph_snapshots":[{"event_id":"sha256:511326c67ff02183153841fe9e2ec2db71f21ad5ebc5457c63325e8413e0227f","target":"graph","created_at":"2026-05-18T02:22:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A goal of systems biology is to understand the dynamics of intracellular systems. Stochastic chemical kinetic models are often utilized to accurately capture the stochastic nature of these systems due to low numbers of molecules. Collecting system data allows for estimation of stochastic chemical kinetic rate parameters. We describe a well-known, but typically impractical data augmentation Markov chain Monte Carlo algorithm for estimating these parameters. The impracticality is due to the use of rejection sampling for latent trajectories with fixed initial and final endpoints which can have di","authors_text":"Jarad Niemi, Matthew Wheeler","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2011-01-21T22:57:52Z","title":"Efficient Bayesian inference in stochastic chemical kinetic models using graphical processing units"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1101.4242","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0a857fd30ddb59de50950ee6127eaad0a3f6afb536e6deaa7e44375b1bb0944e","target":"record","created_at":"2026-05-18T02:22:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1394bd6cc2da2945be12b0a8c8ecb4d7c4bfd6abeb56a6a4a35aa3890a7e6b15","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2011-01-21T22:57:52Z","title_canon_sha256":"1fc7c615384abc4e8fe0cd6fc356ccd8d8ee6207199dae31f30cfb0e42f1a6fc"},"schema_version":"1.0","source":{"id":"1101.4242","kind":"arxiv","version":1}},"canonical_sha256":"d091a0046a4884c9ca583b1debb1e1f3ab66dd6791b5fda992090645ee9046aa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d091a0046a4884c9ca583b1debb1e1f3ab66dd6791b5fda992090645ee9046aa","first_computed_at":"2026-05-18T02:22:50.580098Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:22:50.580098Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"HqDR7CKze3ctsVZa/7pnyn7VeXbbvG0f/mKuybXrYYkS/2/AOUmaOJjUqoHBliNhCWV0k4iTXtfED4Fa7P3HBg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:22:50.580774Z","signed_message":"canonical_sha256_bytes"},"source_id":"1101.4242","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0a857fd30ddb59de50950ee6127eaad0a3f6afb536e6deaa7e44375b1bb0944e","sha256:511326c67ff02183153841fe9e2ec2db71f21ad5ebc5457c63325e8413e0227f"],"state_sha256":"71937e677dd332683e74b848311a87bc1181335bcb92ba29ed4c1d1782916f71"}