{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:2E4J3GKNKMWPSVJ3QKJNPLPBY6","short_pith_number":"pith:2E4J3GKN","schema_version":"1.0","canonical_sha256":"d1389d994d532cf9553b8292d7ade1c783ba657d61cbe86edc081cba2b3f9888","source":{"kind":"arxiv","id":"1407.1627","version":1},"attestation_state":"computed","paper":{"title":"Purifying selection, drift and reversible mutation with arbitrarily high mutation rates","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Brian Charlesworth, Kavita Jain","submitted_at":"2014-07-07T08:54:47Z","abstract_excerpt":"Some species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the resulting high diversity levels within a population (hyperdiversity) mean that standard population genetics methods are not trustworthy. We analyze a population genetics model that incorporates purifying selection, reversible mutations and genetic drift, assuming a stationary population size. We derive analytical results for both population parameters and sample"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1407.1627","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2014-07-07T08:54:47Z","cross_cats_sorted":[],"title_canon_sha256":"a22184e7e8178d022fc343a20803c732dacd9b210010ec574640285239a35f5a","abstract_canon_sha256":"4a5fe06985f1bb1c7f9d5a11123a3d581d651a0afe28cbc330cac3fcce390e85"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:23:04.500086Z","signature_b64":"YywtUInJTFrKVc6V3My0JZPTM1SR4mmogDe58j/cQRrUusLlZYRHcCItYDuHM7+l/x4iiaCl1BcAWhlswpmaCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d1389d994d532cf9553b8292d7ade1c783ba657d61cbe86edc081cba2b3f9888","last_reissued_at":"2026-05-18T01:23:04.499579Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:23:04.499579Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Purifying selection, drift and reversible mutation with arbitrarily high mutation rates","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Brian Charlesworth, Kavita Jain","submitted_at":"2014-07-07T08:54:47Z","abstract_excerpt":"Some species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the resulting high diversity levels within a population (hyperdiversity) mean that standard population genetics methods are not trustworthy. We analyze a population genetics model that incorporates purifying selection, reversible mutations and genetic drift, assuming a stationary population size. We derive analytical results for both population parameters and sample"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1407.1627","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1407.1627","created_at":"2026-05-18T01:23:04.499667+00:00"},{"alias_kind":"arxiv_version","alias_value":"1407.1627v1","created_at":"2026-05-18T01:23:04.499667+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1407.1627","created_at":"2026-05-18T01:23:04.499667+00:00"},{"alias_kind":"pith_short_12","alias_value":"2E4J3GKNKMWP","created_at":"2026-05-18T12:28:09.283467+00:00"},{"alias_kind":"pith_short_16","alias_value":"2E4J3GKNKMWPSVJ3","created_at":"2026-05-18T12:28:09.283467+00:00"},{"alias_kind":"pith_short_8","alias_value":"2E4J3GKN","created_at":"2026-05-18T12:28:09.283467+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6","json":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6.json","graph_json":"https://pith.science/api/pith-number/2E4J3GKNKMWPSVJ3QKJNPLPBY6/graph.json","events_json":"https://pith.science/api/pith-number/2E4J3GKNKMWPSVJ3QKJNPLPBY6/events.json","paper":"https://pith.science/paper/2E4J3GKN"},"agent_actions":{"view_html":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6","download_json":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6.json","view_paper":"https://pith.science/paper/2E4J3GKN","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1407.1627&json=true","fetch_graph":"https://pith.science/api/pith-number/2E4J3GKNKMWPSVJ3QKJNPLPBY6/graph.json","fetch_events":"https://pith.science/api/pith-number/2E4J3GKNKMWPSVJ3QKJNPLPBY6/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6/action/timestamp_anchor","attest_storage":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6/action/storage_attestation","attest_author":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6/action/author_attestation","sign_citation":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6/action/citation_signature","submit_replication":"https://pith.science/pith/2E4J3GKNKMWPSVJ3QKJNPLPBY6/action/replication_record"}},"created_at":"2026-05-18T01:23:04.499667+00:00","updated_at":"2026-05-18T01:23:04.499667+00:00"}