{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:2FV7MVDHEMNK3OGUVLC45IYQ2M","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"65ad3c7262201b3fcd0bb797c62e460ff82a2342654516304544c27eb913e26b","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.PE","submitted_at":"2012-04-23T16:39:49Z","title_canon_sha256":"7d0d0a1aee599bd1cca2156c87b3a78f0c5fec49d412baa27e4eea5b6c7c44d2"},"schema_version":"1.0","source":{"id":"1204.5102","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1204.5102","created_at":"2026-05-18T01:57:47Z"},{"alias_kind":"arxiv_version","alias_value":"1204.5102v1","created_at":"2026-05-18T01:57:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1204.5102","created_at":"2026-05-18T01:57:47Z"},{"alias_kind":"pith_short_12","alias_value":"2FV7MVDHEMNK","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_16","alias_value":"2FV7MVDHEMNK3OGU","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_8","alias_value":"2FV7MVDH","created_at":"2026-05-18T12:26:50Z"}],"graph_snapshots":[{"event_id":"sha256:46f786f62572607561a1225000b62254250de1f6b2ff474a858562b49ab7c429","target":"graph","created_at":"2026-05-18T01:57:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Molecular clock (MC) is a central concept of molecular evolution according to which each gene evolves at a characteristic, near constant rate. Numerous evolutionary studies have demonstrated the validity of MC but also have shown that MC is substantially overdispersed, i.e. lineage-specific deviations of the evolutionary rate of the given gene from the clock greatly exceed the expectation from the sampling error. A fundamental observation of comparative genomics that appears to complement the MC is that the distribution of evolution rates across orthologous genes in pairs of related genomes re","authors_text":"Eugene V. Koonin, Sagi Snir, Yuri I. Wolf","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.PE","submitted_at":"2012-04-23T16:39:49Z","title":"Universal pacemaker of genome evolution"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1204.5102","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5a89c0c9dc64027cdd41a328d3f2485310550bb02f0f0b3d98cb56a8162a6169","target":"record","created_at":"2026-05-18T01:57:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"65ad3c7262201b3fcd0bb797c62e460ff82a2342654516304544c27eb913e26b","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/publicdomain/","primary_cat":"q-bio.PE","submitted_at":"2012-04-23T16:39:49Z","title_canon_sha256":"7d0d0a1aee599bd1cca2156c87b3a78f0c5fec49d412baa27e4eea5b6c7c44d2"},"schema_version":"1.0","source":{"id":"1204.5102","kind":"arxiv","version":1}},"canonical_sha256":"d16bf65467231aadb8d4aac5cea310d33ff27eb9481ea6aade67dc3645251f86","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d16bf65467231aadb8d4aac5cea310d33ff27eb9481ea6aade67dc3645251f86","first_computed_at":"2026-05-18T01:57:47.265522Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:57:47.265522Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XDMpcgUlXbK7DTDKMuCQXdQUSGhKw8k09mqiaMT2zlW9mro0PoJbizOwr2CO+W1ghCRR7hAvzamtvNhB1q7pDg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:57:47.266229Z","signed_message":"canonical_sha256_bytes"},"source_id":"1204.5102","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5a89c0c9dc64027cdd41a328d3f2485310550bb02f0f0b3d98cb56a8162a6169","sha256:46f786f62572607561a1225000b62254250de1f6b2ff474a858562b49ab7c429"],"state_sha256":"9fe54eefc765571347d97a95277ce54400b93ae573ab1365500cdd816608ebd3"}