{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:2GD252NTVNWF24S6BVDQTUN3RW","short_pith_number":"pith:2GD252NT","canonical_record":{"source":{"id":"1208.1054","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-08-05T21:42:51Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"b21d7bcb2d644df6ba3d7344cf3439c7413021911b23865d9cf96d39bb9f641c","abstract_canon_sha256":"4a5b0d514909072fcde3c5acf292d80de5fafe2e9f282d7f5cc81232fab3674c"},"schema_version":"1.0"},"canonical_sha256":"d187aee9b3ab6c5d725e0d4709d1bb8db01d8fc421f0bfecfba97511428e9e9d","source":{"kind":"arxiv","id":"1208.1054","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1208.1054","created_at":"2026-05-18T03:32:45Z"},{"alias_kind":"arxiv_version","alias_value":"1208.1054v4","created_at":"2026-05-18T03:32:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1208.1054","created_at":"2026-05-18T03:32:45Z"},{"alias_kind":"pith_short_12","alias_value":"2GD252NTVNWF","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_16","alias_value":"2GD252NTVNWF24S6","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_8","alias_value":"2GD252NT","created_at":"2026-05-18T12:26:50Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:2GD252NTVNWF24S6BVDQTUN3RW","target":"record","payload":{"canonical_record":{"source":{"id":"1208.1054","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-08-05T21:42:51Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"b21d7bcb2d644df6ba3d7344cf3439c7413021911b23865d9cf96d39bb9f641c","abstract_canon_sha256":"4a5b0d514909072fcde3c5acf292d80de5fafe2e9f282d7f5cc81232fab3674c"},"schema_version":"1.0"},"canonical_sha256":"d187aee9b3ab6c5d725e0d4709d1bb8db01d8fc421f0bfecfba97511428e9e9d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:32:45.128301Z","signature_b64":"eSMW441UJoEOrvPNv7wjELUhfi53eraGkovow3Ri2rRHOir4u1G6l/scSu7FCJ6IzZPRKhiBptR+kThz1AO1CQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d187aee9b3ab6c5d725e0d4709d1bb8db01d8fc421f0bfecfba97511428e9e9d","last_reissued_at":"2026-05-18T03:32:45.127578Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:32:45.127578Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1208.1054","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:32:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Nr4YXdrPfNQfvu+Z/KQvuW81lj7mOdnGiYObUB1ujSSVpqfSr9d87JzD51DM0NvAMfpzijLL1BKluuaItFFnDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T07:14:28.703196Z"},"content_sha256":"db88967d9a79871a6df88954c998a6faeb00d08e87fb37dcf074c4bbea5d3a28","schema_version":"1.0","event_id":"sha256:db88967d9a79871a6df88954c998a6faeb00d08e87fb37dcf074c4bbea5d3a28"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:2GD252NTVNWF24S6BVDQTUN3RW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Transfer Functions for Protein Signal Transduction: Application to a Model of Striatal Neural Plasticity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Gabriele Scheler","submitted_at":"2012-08-05T21:42:51Z","abstract_excerpt":"We present a novel formulation for biochemical reaction networks in the context of signal transduction. The model consists of input-output transfer functions, which are derived from differential equations, using stable equilibria. We select a set of 'source' species, which receive input signals. Signals are transmitted to all other species in the system (the 'target' species) with a specific delay and transmission strength. The delay is computed as the maximal reaction time until a stable equilibrium for the target species is reached, in the context of all other reactions in the system. The tr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1208.1054","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:32:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4kRnz2sSFcZ/p3QGTgejoNLhoMX1ukr4wZw5z4cHpIzpIgcDgdxB6e+X3Vh+L4gQPKKXU6KoWfXcazDM1GS+BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T07:14:28.703862Z"},"content_sha256":"da5ae88d431ed829f341909756da0da8a360bf8b322a5c0ecf89c23b1f21a64a","schema_version":"1.0","event_id":"sha256:da5ae88d431ed829f341909756da0da8a360bf8b322a5c0ecf89c23b1f21a64a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2GD252NTVNWF24S6BVDQTUN3RW/bundle.json","state_url":"https://pith.science/pith/2GD252NTVNWF24S6BVDQTUN3RW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2GD252NTVNWF24S6BVDQTUN3RW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T07:14:28Z","links":{"resolver":"https://pith.science/pith/2GD252NTVNWF24S6BVDQTUN3RW","bundle":"https://pith.science/pith/2GD252NTVNWF24S6BVDQTUN3RW/bundle.json","state":"https://pith.science/pith/2GD252NTVNWF24S6BVDQTUN3RW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2GD252NTVNWF24S6BVDQTUN3RW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:2GD252NTVNWF24S6BVDQTUN3RW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4a5b0d514909072fcde3c5acf292d80de5fafe2e9f282d7f5cc81232fab3674c","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-08-05T21:42:51Z","title_canon_sha256":"b21d7bcb2d644df6ba3d7344cf3439c7413021911b23865d9cf96d39bb9f641c"},"schema_version":"1.0","source":{"id":"1208.1054","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1208.1054","created_at":"2026-05-18T03:32:45Z"},{"alias_kind":"arxiv_version","alias_value":"1208.1054v4","created_at":"2026-05-18T03:32:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1208.1054","created_at":"2026-05-18T03:32:45Z"},{"alias_kind":"pith_short_12","alias_value":"2GD252NTVNWF","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_16","alias_value":"2GD252NTVNWF24S6","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_8","alias_value":"2GD252NT","created_at":"2026-05-18T12:26:50Z"}],"graph_snapshots":[{"event_id":"sha256:da5ae88d431ed829f341909756da0da8a360bf8b322a5c0ecf89c23b1f21a64a","target":"graph","created_at":"2026-05-18T03:32:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We present a novel formulation for biochemical reaction networks in the context of signal transduction. The model consists of input-output transfer functions, which are derived from differential equations, using stable equilibria. We select a set of 'source' species, which receive input signals. Signals are transmitted to all other species in the system (the 'target' species) with a specific delay and transmission strength. The delay is computed as the maximal reaction time until a stable equilibrium for the target species is reached, in the context of all other reactions in the system. The tr","authors_text":"Gabriele Scheler","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-08-05T21:42:51Z","title":"Transfer Functions for Protein Signal Transduction: Application to a Model of Striatal Neural Plasticity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1208.1054","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:db88967d9a79871a6df88954c998a6faeb00d08e87fb37dcf074c4bbea5d3a28","target":"record","created_at":"2026-05-18T03:32:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4a5b0d514909072fcde3c5acf292d80de5fafe2e9f282d7f5cc81232fab3674c","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-08-05T21:42:51Z","title_canon_sha256":"b21d7bcb2d644df6ba3d7344cf3439c7413021911b23865d9cf96d39bb9f641c"},"schema_version":"1.0","source":{"id":"1208.1054","kind":"arxiv","version":4}},"canonical_sha256":"d187aee9b3ab6c5d725e0d4709d1bb8db01d8fc421f0bfecfba97511428e9e9d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d187aee9b3ab6c5d725e0d4709d1bb8db01d8fc421f0bfecfba97511428e9e9d","first_computed_at":"2026-05-18T03:32:45.127578Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:32:45.127578Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"eSMW441UJoEOrvPNv7wjELUhfi53eraGkovow3Ri2rRHOir4u1G6l/scSu7FCJ6IzZPRKhiBptR+kThz1AO1CQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:32:45.128301Z","signed_message":"canonical_sha256_bytes"},"source_id":"1208.1054","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:db88967d9a79871a6df88954c998a6faeb00d08e87fb37dcf074c4bbea5d3a28","sha256:da5ae88d431ed829f341909756da0da8a360bf8b322a5c0ecf89c23b1f21a64a"],"state_sha256":"996406a42ff4d9910df975df279ead6b7afba5c41496dcc7b565b455db80c93b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"N9eTyFaX5SzJKonijl+s/R4IGcIuhBzrt7uh+9SHBrBTa9faCAjrhinjprz9EwSPhDIjL9o+MMiEsqtUeWodBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T07:14:28.707844Z","bundle_sha256":"906fb823220acd10fa9742e93dbfdf8c651c163abec5cb810bb97979486606a4"}}