{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:2GPV27GANZ7Y3QGIVMPH3PHNF3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ecf120dc59d624f4c807dd6879388b3293b4b115c60b9160708b5eb3075ec736","cross_cats_sorted":["q-bio.GN","q-bio.QM","stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ML","submitted_at":"2012-05-09T14:14:22Z","title_canon_sha256":"21892ff41fb96b6ddd7cbfb7c11111bb8aac25628e39241e2c93de87b45aace3"},"schema_version":"1.0","source":{"id":"1205.1989","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1205.1989","created_at":"2026-05-18T03:55:58Z"},{"alias_kind":"arxiv_version","alias_value":"1205.1989v1","created_at":"2026-05-18T03:55:58Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1205.1989","created_at":"2026-05-18T03:55:58Z"},{"alias_kind":"pith_short_12","alias_value":"2GPV27GANZ7Y","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_16","alias_value":"2GPV27GANZ7Y3QGI","created_at":"2026-05-18T12:26:50Z"},{"alias_kind":"pith_short_8","alias_value":"2GPV27GA","created_at":"2026-05-18T12:26:50Z"}],"graph_snapshots":[{"event_id":"sha256:7c658c09141706acf018836fd4a401d79e871f9fe1ca319dec033c30df57f2b4","target":"graph","created_at":"2026-05-18T03:55:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We consider the problem of learning a high-dimensional multi-task regression model, under sparsity constraints induced by presence of grouping structures on the input covariates and on the output predictors. This problem is primarily motivated by expression quantitative trait locus (eQTL) mapping, of which the goal is to discover genetic variations in the genome (inputs) that influence the expression levels of multiple co-expressed genes (outputs), either epistatically, or pleiotropically, or both. A structured input-output lasso (SIOL) model based on an intricate l1/l2-norm penalty over the r","authors_text":"Eric P. Xing, Seunghak Lee","cross_cats":["q-bio.GN","q-bio.QM","stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ML","submitted_at":"2012-05-09T14:14:22Z","title":"Structured Input-Output Lasso, with Application to eQTL Mapping, and a Thresholding Algorithm for Fast Estimation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1205.1989","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:da85236c906e33ac95cf6ad07751c72e77ae73d44cb0d4f3732ac2d96667b1aa","target":"record","created_at":"2026-05-18T03:55:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ecf120dc59d624f4c807dd6879388b3293b4b115c60b9160708b5eb3075ec736","cross_cats_sorted":["q-bio.GN","q-bio.QM","stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ML","submitted_at":"2012-05-09T14:14:22Z","title_canon_sha256":"21892ff41fb96b6ddd7cbfb7c11111bb8aac25628e39241e2c93de87b45aace3"},"schema_version":"1.0","source":{"id":"1205.1989","kind":"arxiv","version":1}},"canonical_sha256":"d19f5d7cc06e7f8dc0c8ab1e7dbced2ecea62ace4922ff3675d829f634ea5e13","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d19f5d7cc06e7f8dc0c8ab1e7dbced2ecea62ace4922ff3675d829f634ea5e13","first_computed_at":"2026-05-18T03:55:58.046119Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:55:58.046119Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"wL6zBrVzWXbpuiMcD6wl5Y13KIX6wc8KcrCsHDSIZvtBh2befm2uKENq1LzY2A+1JxQbHr8Ks5cV9NnGsUeQCA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:55:58.046833Z","signed_message":"canonical_sha256_bytes"},"source_id":"1205.1989","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:da85236c906e33ac95cf6ad07751c72e77ae73d44cb0d4f3732ac2d96667b1aa","sha256:7c658c09141706acf018836fd4a401d79e871f9fe1ca319dec033c30df57f2b4"],"state_sha256":"8a2c41fa4fdbdfd0affaa8cc8698c7113375ae60b5a4c96150c49d2c73ac3bed"}