{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:2HFXT7DS4SOCR5OFJGBRRR544A","short_pith_number":"pith:2HFXT7DS","canonical_record":{"source":{"id":"2411.17789","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-26T15:30:14Z","cross_cats_sorted":[],"title_canon_sha256":"566ac8d681bc9dcce3f85dec202407d20d619361aff67ee173c4e8f3fbba3119","abstract_canon_sha256":"0ec0bf2ca4f3bf4c3fd9570aa8f8bc9579398ef1aad4710bdebba1db9809ac0e"},"schema_version":"1.0"},"canonical_sha256":"d1cb79fc72e49c28f5c5498318c7bce033eb60491573013d3764b855492ec4bf","source":{"kind":"arxiv","id":"2411.17789","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.17789","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"arxiv_version","alias_value":"2411.17789v1","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.17789","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"pith_short_12","alias_value":"2HFXT7DS4SOC","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"pith_short_16","alias_value":"2HFXT7DS4SOCR5OF","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"pith_short_8","alias_value":"2HFXT7DS","created_at":"2026-07-05T09:41:06Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:2HFXT7DS4SOCR5OFJGBRRR544A","target":"record","payload":{"canonical_record":{"source":{"id":"2411.17789","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-26T15:30:14Z","cross_cats_sorted":[],"title_canon_sha256":"566ac8d681bc9dcce3f85dec202407d20d619361aff67ee173c4e8f3fbba3119","abstract_canon_sha256":"0ec0bf2ca4f3bf4c3fd9570aa8f8bc9579398ef1aad4710bdebba1db9809ac0e"},"schema_version":"1.0"},"canonical_sha256":"d1cb79fc72e49c28f5c5498318c7bce033eb60491573013d3764b855492ec4bf","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:41:06.909381Z","signature_b64":"vtxwv8BeI1JfVrGmRLOhF1cMm5K3ddVF7/PpG6UY6sSAHZnntpPglJksHdLYJRMQQEq2/LSlfknTKFg2pQ/+DQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d1cb79fc72e49c28f5c5498318c7bce033eb60491573013d3764b855492ec4bf","last_reissued_at":"2026-07-05T09:41:06.908895Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:41:06.908895Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2411.17789","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:41:06Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"h4RZwqHt/YoNznv1/jbpseZL8YP107ENvv6qV+TjKRE7ES6GJ2IP3mNPzECVoz+CPW3S2FdMwde/z5HePdJMDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T02:50:35.394067Z"},"content_sha256":"347fdf438c316a2b496a2c5450ac8fa564c5f352513b284136573cea7bee6d09","schema_version":"1.0","event_id":"sha256:347fdf438c316a2b496a2c5450ac8fa564c5f352513b284136573cea7bee6d09"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:2HFXT7DS4SOCR5OFJGBRRR544A","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Understanding Immune Dynamics in Liver Transplant Through Mathematical Modeling","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Ali Zarrinpar, Helen Moore, Julia Bruner, Kyle Adams, Mahya Aghaee, Sergio Duarte, Skylar Grey","submitted_at":"2024-11-26T15:30:14Z","abstract_excerpt":"Liver transplant can be a life-saving procedure for patients with end-stage liver disease. With the introduction of modern immunosuppressive therapies, short-term survival has significantly improved. However, long-term survival has not substantially improved in decades. Consequently, causes of death are now more likely to be due to the toxicities and side-effects of long-term immunosuppression rather than rejection. In order to study the balance of immunosuppression and rejection, we developed the first mechanistic mathematical model of liver transplant and immune system dynamics. We determine"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.17789","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2411.17789/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:41:06Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"njtcXvRMrlFQDqpfmZGgf/S6krKIdoDvxu2MRQ4jgckHxihn+z9bPXoiLVRUpYZZqZdq6p8CGGb2Aaznagj3DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T02:50:35.394765Z"},"content_sha256":"3f76f6de3a7d3aa466c10123ab1151ba7113ad9ef7e0502201ef8ad5f709a7b9","schema_version":"1.0","event_id":"sha256:3f76f6de3a7d3aa466c10123ab1151ba7113ad9ef7e0502201ef8ad5f709a7b9"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2HFXT7DS4SOCR5OFJGBRRR544A/bundle.json","state_url":"https://pith.science/pith/2HFXT7DS4SOCR5OFJGBRRR544A/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2HFXT7DS4SOCR5OFJGBRRR544A/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-13T02:50:35Z","links":{"resolver":"https://pith.science/pith/2HFXT7DS4SOCR5OFJGBRRR544A","bundle":"https://pith.science/pith/2HFXT7DS4SOCR5OFJGBRRR544A/bundle.json","state":"https://pith.science/pith/2HFXT7DS4SOCR5OFJGBRRR544A/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2HFXT7DS4SOCR5OFJGBRRR544A/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:2HFXT7DS4SOCR5OFJGBRRR544A","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0ec0bf2ca4f3bf4c3fd9570aa8f8bc9579398ef1aad4710bdebba1db9809ac0e","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-26T15:30:14Z","title_canon_sha256":"566ac8d681bc9dcce3f85dec202407d20d619361aff67ee173c4e8f3fbba3119"},"schema_version":"1.0","source":{"id":"2411.17789","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.17789","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"arxiv_version","alias_value":"2411.17789v1","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.17789","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"pith_short_12","alias_value":"2HFXT7DS4SOC","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"pith_short_16","alias_value":"2HFXT7DS4SOCR5OF","created_at":"2026-07-05T09:41:06Z"},{"alias_kind":"pith_short_8","alias_value":"2HFXT7DS","created_at":"2026-07-05T09:41:06Z"}],"graph_snapshots":[{"event_id":"sha256:3f76f6de3a7d3aa466c10123ab1151ba7113ad9ef7e0502201ef8ad5f709a7b9","target":"graph","created_at":"2026-07-05T09:41:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.17789/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Liver transplant can be a life-saving procedure for patients with end-stage liver disease. With the introduction of modern immunosuppressive therapies, short-term survival has significantly improved. However, long-term survival has not substantially improved in decades. Consequently, causes of death are now more likely to be due to the toxicities and side-effects of long-term immunosuppression rather than rejection. In order to study the balance of immunosuppression and rejection, we developed the first mechanistic mathematical model of liver transplant and immune system dynamics. We determine","authors_text":"Ali Zarrinpar, Helen Moore, Julia Bruner, Kyle Adams, Mahya Aghaee, Sergio Duarte, Skylar Grey","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-26T15:30:14Z","title":"Understanding Immune Dynamics in Liver Transplant Through Mathematical Modeling"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.17789","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:347fdf438c316a2b496a2c5450ac8fa564c5f352513b284136573cea7bee6d09","target":"record","created_at":"2026-07-05T09:41:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0ec0bf2ca4f3bf4c3fd9570aa8f8bc9579398ef1aad4710bdebba1db9809ac0e","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-26T15:30:14Z","title_canon_sha256":"566ac8d681bc9dcce3f85dec202407d20d619361aff67ee173c4e8f3fbba3119"},"schema_version":"1.0","source":{"id":"2411.17789","kind":"arxiv","version":1}},"canonical_sha256":"d1cb79fc72e49c28f5c5498318c7bce033eb60491573013d3764b855492ec4bf","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d1cb79fc72e49c28f5c5498318c7bce033eb60491573013d3764b855492ec4bf","first_computed_at":"2026-07-05T09:41:06.908895Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:41:06.908895Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vtxwv8BeI1JfVrGmRLOhF1cMm5K3ddVF7/PpG6UY6sSAHZnntpPglJksHdLYJRMQQEq2/LSlfknTKFg2pQ/+DQ==","signature_status":"signed_v1","signed_at":"2026-07-05T09:41:06.909381Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.17789","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:347fdf438c316a2b496a2c5450ac8fa564c5f352513b284136573cea7bee6d09","sha256:3f76f6de3a7d3aa466c10123ab1151ba7113ad9ef7e0502201ef8ad5f709a7b9"],"state_sha256":"cee3c01e12825d1977c0af0796b63e298447aa675c79d1a85f652c5ab90cd698"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"B7yDNkFlIuDNq9jE8ChuRT1UbSCsoWNfB8MeYTVW2BdK/WobhR1Fg/JYJriiK+kNJTO07Tu1lelYdWQX5JkCDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-13T02:50:35.400996Z","bundle_sha256":"fce92ec04019da812a3117ddb6f6ec8d6c55fc6fc059d140257fd546fe2995a9"}}