{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:2KSZES64BSGLKIXN45HJPPSZC2","short_pith_number":"pith:2KSZES64","canonical_record":{"source":{"id":"2505.00037","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-04-29T16:35:38Z","cross_cats_sorted":["cs.LG","q-bio.QM"],"title_canon_sha256":"494a62c155240860ecb3da19bb0c1c1f7946668a92b53fdaca1252c2dcf681b0","abstract_canon_sha256":"ca31513d5c34ddca10b0a741ab418ae34656b88b662dfc58809f7e54e4ca4a7e"},"schema_version":"1.0"},"canonical_sha256":"d2a5924bdc0c8cb522ede74e97be5916bde3b15506134cb131c339377730c3a7","source":{"kind":"arxiv","id":"2505.00037","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.00037","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"arxiv_version","alias_value":"2505.00037v1","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.00037","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"pith_short_12","alias_value":"2KSZES64BSGL","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"pith_short_16","alias_value":"2KSZES64BSGLKIXN","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"pith_short_8","alias_value":"2KSZES64","created_at":"2026-07-05T10:56:40Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:2KSZES64BSGLKIXN45HJPPSZC2","target":"record","payload":{"canonical_record":{"source":{"id":"2505.00037","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-04-29T16:35:38Z","cross_cats_sorted":["cs.LG","q-bio.QM"],"title_canon_sha256":"494a62c155240860ecb3da19bb0c1c1f7946668a92b53fdaca1252c2dcf681b0","abstract_canon_sha256":"ca31513d5c34ddca10b0a741ab418ae34656b88b662dfc58809f7e54e4ca4a7e"},"schema_version":"1.0"},"canonical_sha256":"d2a5924bdc0c8cb522ede74e97be5916bde3b15506134cb131c339377730c3a7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:56:40.935164Z","signature_b64":"9F+u7FATtUEDMdwScv778nLhaqC2jHKwMnEL9KF7abt+kjAVFMBvBImYRNfKNP16FxpJJIvtO9uTbsHyGJiJAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d2a5924bdc0c8cb522ede74e97be5916bde3b15506134cb131c339377730c3a7","last_reissued_at":"2026-07-05T10:56:40.934685Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:56:40.934685Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2505.00037","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:56:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"VxDiPfAMu4vIIpUMw4HEmFKfb9TmVVhkt9QrmeLjN02JfH4iv296i37OVmqvQzRJ8F1a64XRfpS/CyVXPW0ZDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T12:15:34.282414Z"},"content_sha256":"85a5ddb551d3b11316f41e7197b68b1e8ec6b56d0cd58e07f186e350024a0b37","schema_version":"1.0","event_id":"sha256:85a5ddb551d3b11316f41e7197b68b1e8ec6b56d0cd58e07f186e350024a0b37"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:2KSZES64BSGLKIXN45HJPPSZC2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Can a Quantum Support Vector Machine algorithm be utilized to identify Key Biomarkers from Multi-Omics data of COVID19 patients?","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG","q-bio.QM"],"primary_cat":"quant-ph","authors_text":"Chansu Yu, Jae U. Jung, Junggu Choi, Kyle L. Jung, Lara Jehi, Serpil C. Erzurum, Suan-Sin Foo, Suzy AA Comhair, Weiqiang Chen","submitted_at":"2025-04-29T16:35:38Z","abstract_excerpt":"Identifying key biomarkers for COVID-19 from high-dimensional multi-omics data is critical for advancing both diagnostic and pathogenesis research. In this study, we evaluated the applicability of the Quantum Support Vector Machine (QSVM) algorithm for biomarker-based classification of COVID-19. Proteomic and metabolomic biomarkers from two independent datasets were ranked by importance using ridge regression and grouped accordingly. The top- and bottom-ranked biomarker sets were then used to train and evaluate both classical SVM (CSVM) and QSVM models, serving as predictive and negative contr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.00037","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.00037/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:56:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9/x4GQ2abSFHnQcrwpq9g0Y3WqAutw4qKVvaz2dPft5dDvEUb2jeHRipZt79B7tEF96ivaS9xJz59g0DhXAhAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-23T12:15:34.283268Z"},"content_sha256":"4c19a6f19d79690fad29a2a699998f989f9cbf8f625b9541b3050e749a20e94c","schema_version":"1.0","event_id":"sha256:4c19a6f19d79690fad29a2a699998f989f9cbf8f625b9541b3050e749a20e94c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2KSZES64BSGLKIXN45HJPPSZC2/bundle.json","state_url":"https://pith.science/pith/2KSZES64BSGLKIXN45HJPPSZC2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2KSZES64BSGLKIXN45HJPPSZC2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-23T12:15:34Z","links":{"resolver":"https://pith.science/pith/2KSZES64BSGLKIXN45HJPPSZC2","bundle":"https://pith.science/pith/2KSZES64BSGLKIXN45HJPPSZC2/bundle.json","state":"https://pith.science/pith/2KSZES64BSGLKIXN45HJPPSZC2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2KSZES64BSGLKIXN45HJPPSZC2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:2KSZES64BSGLKIXN45HJPPSZC2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ca31513d5c34ddca10b0a741ab418ae34656b88b662dfc58809f7e54e4ca4a7e","cross_cats_sorted":["cs.LG","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-04-29T16:35:38Z","title_canon_sha256":"494a62c155240860ecb3da19bb0c1c1f7946668a92b53fdaca1252c2dcf681b0"},"schema_version":"1.0","source":{"id":"2505.00037","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.00037","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"arxiv_version","alias_value":"2505.00037v1","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.00037","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"pith_short_12","alias_value":"2KSZES64BSGL","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"pith_short_16","alias_value":"2KSZES64BSGLKIXN","created_at":"2026-07-05T10:56:40Z"},{"alias_kind":"pith_short_8","alias_value":"2KSZES64","created_at":"2026-07-05T10:56:40Z"}],"graph_snapshots":[{"event_id":"sha256:4c19a6f19d79690fad29a2a699998f989f9cbf8f625b9541b3050e749a20e94c","target":"graph","created_at":"2026-07-05T10:56:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.00037/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Identifying key biomarkers for COVID-19 from high-dimensional multi-omics data is critical for advancing both diagnostic and pathogenesis research. In this study, we evaluated the applicability of the Quantum Support Vector Machine (QSVM) algorithm for biomarker-based classification of COVID-19. Proteomic and metabolomic biomarkers from two independent datasets were ranked by importance using ridge regression and grouped accordingly. The top- and bottom-ranked biomarker sets were then used to train and evaluate both classical SVM (CSVM) and QSVM models, serving as predictive and negative contr","authors_text":"Chansu Yu, Jae U. Jung, Junggu Choi, Kyle L. Jung, Lara Jehi, Serpil C. Erzurum, Suan-Sin Foo, Suzy AA Comhair, Weiqiang Chen","cross_cats":["cs.LG","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-04-29T16:35:38Z","title":"Can a Quantum Support Vector Machine algorithm be utilized to identify Key Biomarkers from Multi-Omics data of COVID19 patients?"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.00037","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:85a5ddb551d3b11316f41e7197b68b1e8ec6b56d0cd58e07f186e350024a0b37","target":"record","created_at":"2026-07-05T10:56:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ca31513d5c34ddca10b0a741ab418ae34656b88b662dfc58809f7e54e4ca4a7e","cross_cats_sorted":["cs.LG","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-04-29T16:35:38Z","title_canon_sha256":"494a62c155240860ecb3da19bb0c1c1f7946668a92b53fdaca1252c2dcf681b0"},"schema_version":"1.0","source":{"id":"2505.00037","kind":"arxiv","version":1}},"canonical_sha256":"d2a5924bdc0c8cb522ede74e97be5916bde3b15506134cb131c339377730c3a7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d2a5924bdc0c8cb522ede74e97be5916bde3b15506134cb131c339377730c3a7","first_computed_at":"2026-07-05T10:56:40.934685Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:56:40.934685Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"9F+u7FATtUEDMdwScv778nLhaqC2jHKwMnEL9KF7abt+kjAVFMBvBImYRNfKNP16FxpJJIvtO9uTbsHyGJiJAQ==","signature_status":"signed_v1","signed_at":"2026-07-05T10:56:40.935164Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.00037","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:85a5ddb551d3b11316f41e7197b68b1e8ec6b56d0cd58e07f186e350024a0b37","sha256:4c19a6f19d79690fad29a2a699998f989f9cbf8f625b9541b3050e749a20e94c"],"state_sha256":"c705aa09f49540590bb6ac6534df5e3453f3da8fbce736a477346beca35b17b6"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2Ypr9WpN14fn25JSFfiJlX4frdKnL6AB5Fs+ZX4J52GtctM5FfObu9YkHZQs+hb7flhDoBg88ZosasjEN5VDDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-23T12:15:34.288237Z","bundle_sha256":"5b1fe695687bf6598a0368b983df2c5428e7d7eb54c4d0de43006402d7514ac7"}}