{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:2LES2E2WEC77PKVSTUZNJ7V7XF","short_pith_number":"pith:2LES2E2W","canonical_record":{"source":{"id":"1103.3042","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2011-03-15T20:57:41Z","cross_cats_sorted":["physics.bio-ph","physics.chem-ph"],"title_canon_sha256":"3be9eac168a8eed234f1e2c48491a1324d4bf45ed7a2078d1df43eb15270c7ad","abstract_canon_sha256":"e744b4f54aebbd445d61c3873844e87564894baf02572bb6d8dabe9717d87a17"},"schema_version":"1.0"},"canonical_sha256":"d2c92d135620bff7aab29d32d4febfb96b3b83c237e1d9a6ae14928b404f10ad","source":{"kind":"arxiv","id":"1103.3042","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1103.3042","created_at":"2026-05-18T04:20:24Z"},{"alias_kind":"arxiv_version","alias_value":"1103.3042v2","created_at":"2026-05-18T04:20:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1103.3042","created_at":"2026-05-18T04:20:24Z"},{"alias_kind":"pith_short_12","alias_value":"2LES2E2WEC77","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_16","alias_value":"2LES2E2WEC77PKVS","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_8","alias_value":"2LES2E2W","created_at":"2026-05-18T12:26:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:2LES2E2WEC77PKVSTUZNJ7V7XF","target":"record","payload":{"canonical_record":{"source":{"id":"1103.3042","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2011-03-15T20:57:41Z","cross_cats_sorted":["physics.bio-ph","physics.chem-ph"],"title_canon_sha256":"3be9eac168a8eed234f1e2c48491a1324d4bf45ed7a2078d1df43eb15270c7ad","abstract_canon_sha256":"e744b4f54aebbd445d61c3873844e87564894baf02572bb6d8dabe9717d87a17"},"schema_version":"1.0"},"canonical_sha256":"d2c92d135620bff7aab29d32d4febfb96b3b83c237e1d9a6ae14928b404f10ad","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:20:24.625758Z","signature_b64":"QbIIu6QF9+t6KcsASpbWgkXbTceucOzbyzaQUhn8Gqj3/AZJA8S7bQmZy3n+yp5zpeDiwXj6+ackDS3G/q4NBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d2c92d135620bff7aab29d32d4febfb96b3b83c237e1d9a6ae14928b404f10ad","last_reissued_at":"2026-05-18T04:20:24.624787Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:20:24.624787Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1103.3042","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:20:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"u/lSRuSooWxv6fDnz3jnkbVhxdfz+/14QUL2t89SdnXSCW5FmxZQVBvH8AS4xTQKAz9RGVGQE9oGKwQrIP0YDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T00:29:45.553241Z"},"content_sha256":"7eaab2f2370341df70f0fef3654c23482a8d6ee691d081f139a41d99a54e4a04","schema_version":"1.0","event_id":"sha256:7eaab2f2370341df70f0fef3654c23482a8d6ee691d081f139a41d99a54e4a04"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:2LES2E2WEC77PKVSTUZNJ7V7XF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Four small puzzles that Rosetta doesn't solve","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","physics.chem-ph"],"primary_cat":"q-bio.BM","authors_text":"Rhiju Das","submitted_at":"2011-03-15T20:57:41Z","abstract_excerpt":"A complete macromolecule modeling package must be able to solve the simplest structure prediction problems. Despite recent successes in high resolution structure modeling and design, the Rosetta software suite fares poorly on deceptively small protein and RNA puzzles, some as small as four residues. To illustrate these problems, this manuscript presents extensive Rosetta results for four well-defined test cases: the 20-residue mini-protein Trp cage, an even smaller disulfide-stabilized conotoxin, the reactive loop of a serine protease inhibitor, and a UUCG RNA tetraloop. In contrast to previou"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1103.3042","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:20:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YikVjSo8WBXywYuYsHPYIN9om7/jpQUIlAj7dZkUWhbFKrPzgxCi+hS51rWcwjW+kI/vUTcMdb/E4clIx5xbDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T00:29:45.553976Z"},"content_sha256":"f79a3b83d3db307e0fcf9570d11c0be55d19ccbfc6c4d79432057b6e760985b9","schema_version":"1.0","event_id":"sha256:f79a3b83d3db307e0fcf9570d11c0be55d19ccbfc6c4d79432057b6e760985b9"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2LES2E2WEC77PKVSTUZNJ7V7XF/bundle.json","state_url":"https://pith.science/pith/2LES2E2WEC77PKVSTUZNJ7V7XF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2LES2E2WEC77PKVSTUZNJ7V7XF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-30T00:29:45Z","links":{"resolver":"https://pith.science/pith/2LES2E2WEC77PKVSTUZNJ7V7XF","bundle":"https://pith.science/pith/2LES2E2WEC77PKVSTUZNJ7V7XF/bundle.json","state":"https://pith.science/pith/2LES2E2WEC77PKVSTUZNJ7V7XF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2LES2E2WEC77PKVSTUZNJ7V7XF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:2LES2E2WEC77PKVSTUZNJ7V7XF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e744b4f54aebbd445d61c3873844e87564894baf02572bb6d8dabe9717d87a17","cross_cats_sorted":["physics.bio-ph","physics.chem-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2011-03-15T20:57:41Z","title_canon_sha256":"3be9eac168a8eed234f1e2c48491a1324d4bf45ed7a2078d1df43eb15270c7ad"},"schema_version":"1.0","source":{"id":"1103.3042","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1103.3042","created_at":"2026-05-18T04:20:24Z"},{"alias_kind":"arxiv_version","alias_value":"1103.3042v2","created_at":"2026-05-18T04:20:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1103.3042","created_at":"2026-05-18T04:20:24Z"},{"alias_kind":"pith_short_12","alias_value":"2LES2E2WEC77","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_16","alias_value":"2LES2E2WEC77PKVS","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_8","alias_value":"2LES2E2W","created_at":"2026-05-18T12:26:18Z"}],"graph_snapshots":[{"event_id":"sha256:f79a3b83d3db307e0fcf9570d11c0be55d19ccbfc6c4d79432057b6e760985b9","target":"graph","created_at":"2026-05-18T04:20:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A complete macromolecule modeling package must be able to solve the simplest structure prediction problems. Despite recent successes in high resolution structure modeling and design, the Rosetta software suite fares poorly on deceptively small protein and RNA puzzles, some as small as four residues. To illustrate these problems, this manuscript presents extensive Rosetta results for four well-defined test cases: the 20-residue mini-protein Trp cage, an even smaller disulfide-stabilized conotoxin, the reactive loop of a serine protease inhibitor, and a UUCG RNA tetraloop. In contrast to previou","authors_text":"Rhiju Das","cross_cats":["physics.bio-ph","physics.chem-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2011-03-15T20:57:41Z","title":"Four small puzzles that Rosetta doesn't solve"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1103.3042","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:7eaab2f2370341df70f0fef3654c23482a8d6ee691d081f139a41d99a54e4a04","target":"record","created_at":"2026-05-18T04:20:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e744b4f54aebbd445d61c3873844e87564894baf02572bb6d8dabe9717d87a17","cross_cats_sorted":["physics.bio-ph","physics.chem-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2011-03-15T20:57:41Z","title_canon_sha256":"3be9eac168a8eed234f1e2c48491a1324d4bf45ed7a2078d1df43eb15270c7ad"},"schema_version":"1.0","source":{"id":"1103.3042","kind":"arxiv","version":2}},"canonical_sha256":"d2c92d135620bff7aab29d32d4febfb96b3b83c237e1d9a6ae14928b404f10ad","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d2c92d135620bff7aab29d32d4febfb96b3b83c237e1d9a6ae14928b404f10ad","first_computed_at":"2026-05-18T04:20:24.624787Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:20:24.624787Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"QbIIu6QF9+t6KcsASpbWgkXbTceucOzbyzaQUhn8Gqj3/AZJA8S7bQmZy3n+yp5zpeDiwXj6+ackDS3G/q4NBg==","signature_status":"signed_v1","signed_at":"2026-05-18T04:20:24.625758Z","signed_message":"canonical_sha256_bytes"},"source_id":"1103.3042","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:7eaab2f2370341df70f0fef3654c23482a8d6ee691d081f139a41d99a54e4a04","sha256:f79a3b83d3db307e0fcf9570d11c0be55d19ccbfc6c4d79432057b6e760985b9"],"state_sha256":"f56a85a7807bd21cca5559743d4169a0853fdf62721bf307f0ed8b3ad9042a9d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7c7V0OSNDhhLO9pJMGNk1n4d6w65l7fsyXBzhRnucAZ9BnB13yeC4kDJcFPTAChcy27RfjOnJhDUouz+Aj/aBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-30T00:29:45.557430Z","bundle_sha256":"dae4889ce014584aea6259e313fabb49031910ff540f7a845a03b5389814b671"}}