{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:2LL2WTC3KMNAGOJ7C4AU77QGNN","short_pith_number":"pith:2LL2WTC3","canonical_record":{"source":{"id":"1711.00069","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-10-31T19:40:29Z","cross_cats_sorted":["eess.IV","q-bio.QM"],"title_canon_sha256":"1598c464f883817cc888825a3991e29ae5cfc85a5e0342161f516fefdb6a010a","abstract_canon_sha256":"9ec7120997855b487df26b2338a97b30ccf72a19b2fd7cf2355939a981bbc7b1"},"schema_version":"1.0"},"canonical_sha256":"d2d7ab4c5b531a03393f17014ffe066b6da09d6665c2a72d249b36353533f6bd","source":{"kind":"arxiv","id":"1711.00069","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1711.00069","created_at":"2026-05-17T23:50:49Z"},{"alias_kind":"arxiv_version","alias_value":"1711.00069v2","created_at":"2026-05-17T23:50:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.00069","created_at":"2026-05-17T23:50:49Z"},{"alias_kind":"pith_short_12","alias_value":"2LL2WTC3KMNA","created_at":"2026-05-18T12:30:55Z"},{"alias_kind":"pith_short_16","alias_value":"2LL2WTC3KMNAGOJ7","created_at":"2026-05-18T12:30:55Z"},{"alias_kind":"pith_short_8","alias_value":"2LL2WTC3","created_at":"2026-05-18T12:30:55Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:2LL2WTC3KMNAGOJ7C4AU77QGNN","target":"record","payload":{"canonical_record":{"source":{"id":"1711.00069","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-10-31T19:40:29Z","cross_cats_sorted":["eess.IV","q-bio.QM"],"title_canon_sha256":"1598c464f883817cc888825a3991e29ae5cfc85a5e0342161f516fefdb6a010a","abstract_canon_sha256":"9ec7120997855b487df26b2338a97b30ccf72a19b2fd7cf2355939a981bbc7b1"},"schema_version":"1.0"},"canonical_sha256":"d2d7ab4c5b531a03393f17014ffe066b6da09d6665c2a72d249b36353533f6bd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:50:49.395670Z","signature_b64":"/jPsBuEzauEYEFoB+++0l4m3KyKb5RKaNCrYFuBit//wRjOe51tY2gMgXbjLqOILoOpZiMzzUYuOlmJOpDALDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d2d7ab4c5b531a03393f17014ffe066b6da09d6665c2a72d249b36353533f6bd","last_reissued_at":"2026-05-17T23:50:49.395086Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:50:49.395086Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1711.00069","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:50:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kIXzh44H1d33ViNG+7nAtw8BSbU6u40N1kh1JudEaArVL60kali9FH21F1scQLsbBLH7tz9XZ1c6lOkw8H2TDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T12:43:50.115485Z"},"content_sha256":"4f098e89d773072841d74863609b9c68c498f0c2900938b0cfda1460d95b27d6","schema_version":"1.0","event_id":"sha256:4f098e89d773072841d74863609b9c68c498f0c2900938b0cfda1460d95b27d6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:2LL2WTC3KMNAGOJ7C4AU77QGNN","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Spatially Adaptive Colocalization Analysis in Dual-Color Fluorescence Microscopy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["eess.IV","q-bio.QM"],"primary_cat":"stat.ME","authors_text":"Ellen T. Arena, Jordan T. Becker, Kevin W. Eliceiri, Ming Yuan, Nathan M. Sherer, Shulei Wang, William M. Bement","submitted_at":"2017-10-31T19:40:29Z","abstract_excerpt":"Colocalization analysis aims to study complex spatial associations between bio-molecules via optical imaging techniques. However, existing colocalization analysis workflows only assess an average degree of colocalization within a certain region of interest and ignore the unique and valuable spatial information offered by microscopy. In the current work, we introduce a new framework for colocalization analysis that allows us to quantify colocalization levels at each individual location and automatically identify pixels or regions where colocalization occurs. The framework, referred to as spatia"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.00069","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:50:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"taCZccjnYx4p7aJKpMAKHI44SXvzbaenBinNUVQTOG+Oh2h3da5uS+tU6G6r0qixOS2Qm7JDSQJu65qmgFOgBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-30T12:43:50.116149Z"},"content_sha256":"36d1d91e2620616b338f07beed191b40e1555c4ababb8ef205fcf9cd9c7623a5","schema_version":"1.0","event_id":"sha256:36d1d91e2620616b338f07beed191b40e1555c4ababb8ef205fcf9cd9c7623a5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN/bundle.json","state_url":"https://pith.science/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-30T12:43:50Z","links":{"resolver":"https://pith.science/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN","bundle":"https://pith.science/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN/bundle.json","state":"https://pith.science/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2LL2WTC3KMNAGOJ7C4AU77QGNN/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:2LL2WTC3KMNAGOJ7C4AU77QGNN","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9ec7120997855b487df26b2338a97b30ccf72a19b2fd7cf2355939a981bbc7b1","cross_cats_sorted":["eess.IV","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-10-31T19:40:29Z","title_canon_sha256":"1598c464f883817cc888825a3991e29ae5cfc85a5e0342161f516fefdb6a010a"},"schema_version":"1.0","source":{"id":"1711.00069","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1711.00069","created_at":"2026-05-17T23:50:49Z"},{"alias_kind":"arxiv_version","alias_value":"1711.00069v2","created_at":"2026-05-17T23:50:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1711.00069","created_at":"2026-05-17T23:50:49Z"},{"alias_kind":"pith_short_12","alias_value":"2LL2WTC3KMNA","created_at":"2026-05-18T12:30:55Z"},{"alias_kind":"pith_short_16","alias_value":"2LL2WTC3KMNAGOJ7","created_at":"2026-05-18T12:30:55Z"},{"alias_kind":"pith_short_8","alias_value":"2LL2WTC3","created_at":"2026-05-18T12:30:55Z"}],"graph_snapshots":[{"event_id":"sha256:36d1d91e2620616b338f07beed191b40e1555c4ababb8ef205fcf9cd9c7623a5","target":"graph","created_at":"2026-05-17T23:50:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Colocalization analysis aims to study complex spatial associations between bio-molecules via optical imaging techniques. However, existing colocalization analysis workflows only assess an average degree of colocalization within a certain region of interest and ignore the unique and valuable spatial information offered by microscopy. In the current work, we introduce a new framework for colocalization analysis that allows us to quantify colocalization levels at each individual location and automatically identify pixels or regions where colocalization occurs. The framework, referred to as spatia","authors_text":"Ellen T. Arena, Jordan T. Becker, Kevin W. Eliceiri, Ming Yuan, Nathan M. Sherer, Shulei Wang, William M. Bement","cross_cats":["eess.IV","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-10-31T19:40:29Z","title":"Spatially Adaptive Colocalization Analysis in Dual-Color Fluorescence Microscopy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1711.00069","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4f098e89d773072841d74863609b9c68c498f0c2900938b0cfda1460d95b27d6","target":"record","created_at":"2026-05-17T23:50:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9ec7120997855b487df26b2338a97b30ccf72a19b2fd7cf2355939a981bbc7b1","cross_cats_sorted":["eess.IV","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-10-31T19:40:29Z","title_canon_sha256":"1598c464f883817cc888825a3991e29ae5cfc85a5e0342161f516fefdb6a010a"},"schema_version":"1.0","source":{"id":"1711.00069","kind":"arxiv","version":2}},"canonical_sha256":"d2d7ab4c5b531a03393f17014ffe066b6da09d6665c2a72d249b36353533f6bd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d2d7ab4c5b531a03393f17014ffe066b6da09d6665c2a72d249b36353533f6bd","first_computed_at":"2026-05-17T23:50:49.395086Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:50:49.395086Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"/jPsBuEzauEYEFoB+++0l4m3KyKb5RKaNCrYFuBit//wRjOe51tY2gMgXbjLqOILoOpZiMzzUYuOlmJOpDALDg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:50:49.395670Z","signed_message":"canonical_sha256_bytes"},"source_id":"1711.00069","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4f098e89d773072841d74863609b9c68c498f0c2900938b0cfda1460d95b27d6","sha256:36d1d91e2620616b338f07beed191b40e1555c4ababb8ef205fcf9cd9c7623a5"],"state_sha256":"e950bffc62b6d534e115f964ee18f9b6f9dfcdd5a36056b7e9a8f686702ee4a1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+vCEnc0SzqSdicgYxRmGoY1B4uyFqbaFZa9x8hKrjtX97LqkipzJpxrEmHvBNU5OKqa0gc/qAtsc1YxBpu9XAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-30T12:43:50.119660Z","bundle_sha256":"ff004574b21d451af6f00a19d79868208234d0d26cfcfe3ce8b291e85b830e81"}}