{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:2O4BQTFDDRASOROJAYRD2ASKR7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3be2cabfdc3c41a1d77ad1e904acc81b2a22c8c4c10077e71f4d726aa6e5e08b","cross_cats_sorted":["stat.CO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-06-20T13:02:46Z","title_canon_sha256":"77a3520f907ccd8231ac98752098fae0bbc677ce25a91e58dc49d16054add013"},"schema_version":"1.0","source":{"id":"1106.3885","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1106.3885","created_at":"2026-05-18T03:52:51Z"},{"alias_kind":"arxiv_version","alias_value":"1106.3885v3","created_at":"2026-05-18T03:52:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1106.3885","created_at":"2026-05-18T03:52:51Z"},{"alias_kind":"pith_short_12","alias_value":"2O4BQTFDDRAS","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_16","alias_value":"2O4BQTFDDRASOROJ","created_at":"2026-05-18T12:26:18Z"},{"alias_kind":"pith_short_8","alias_value":"2O4BQTFD","created_at":"2026-05-18T12:26:18Z"}],"graph_snapshots":[{"event_id":"sha256:2772523c121e30c8dc37f5e8b3b9c4b3298fe718537a92a1632d6c154d9a027b","target":"graph","created_at":"2026-05-18T03:52:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We propose a flexible and identifiable version of the two-groups model, motivated by hierarchical Bayes considerations, that features an empirical null and a semiparametric mixture model for the non-null cases. We use a computationally efficient predictive recursion marginal likelihood procedure to estimate the model parameters, even the nonparametric mixing distribution. This leads to a nonparametric empirical Bayes testing procedure, which we call PRtest, based on thresholding the estimated local false discovery rates. Simulations and real-data examples demonstrate that, compared to existing","authors_text":"Ryan Martin, Surya T. Tokdar","cross_cats":["stat.CO"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-06-20T13:02:46Z","title":"A nonparametric empirical Bayes framework for large-scale multiple testing"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1106.3885","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:007db1c9e1a4768015ff412ca46c33f6b75fd2e14fdb34b638221bedefcfa629","target":"record","created_at":"2026-05-18T03:52:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3be2cabfdc3c41a1d77ad1e904acc81b2a22c8c4c10077e71f4d726aa6e5e08b","cross_cats_sorted":["stat.CO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-06-20T13:02:46Z","title_canon_sha256":"77a3520f907ccd8231ac98752098fae0bbc677ce25a91e58dc49d16054add013"},"schema_version":"1.0","source":{"id":"1106.3885","kind":"arxiv","version":3}},"canonical_sha256":"d3b8184ca31c412745c906223d024a8ff8254e867473c6de1a8e2a690be8daff","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d3b8184ca31c412745c906223d024a8ff8254e867473c6de1a8e2a690be8daff","first_computed_at":"2026-05-18T03:52:51.295294Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:52:51.295294Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"RwFvNspmhlCCK3inIYi7gBSUir7Q91o3IEFtjMrVTlnzbasFRo6hWlFt1u9ekJAQ3n0hJ1+qimuHxQJoqvtzBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:52:51.295983Z","signed_message":"canonical_sha256_bytes"},"source_id":"1106.3885","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:007db1c9e1a4768015ff412ca46c33f6b75fd2e14fdb34b638221bedefcfa629","sha256:2772523c121e30c8dc37f5e8b3b9c4b3298fe718537a92a1632d6c154d9a027b"],"state_sha256":"5fee41cf9c0f83c978531aef533aff49d413f7ebd41386267f5c3d4e1124337b"}