{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:2OYCR4A2XT4N27F4XBGLHYNVDZ","short_pith_number":"pith:2OYCR4A2","canonical_record":{"source":{"id":"2505.09197","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.AP","submitted_at":"2025-05-14T07:18:06Z","cross_cats_sorted":["eess.IV"],"title_canon_sha256":"96c7792296e72e58e40b6de7a0cd6a8b82bc7e1da668d30d483a4468025211da","abstract_canon_sha256":"a0bcfaa38fa510053c06cb003382db54d9a8049bb319b63004e1da9887b3c01c"},"schema_version":"1.0"},"canonical_sha256":"d3b028f01abcf8dd7cbcb84cb3e1b51e7b889c5db6ebd18114e3af89f6d16af1","source":{"kind":"arxiv","id":"2505.09197","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.09197","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"arxiv_version","alias_value":"2505.09197v1","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.09197","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"pith_short_12","alias_value":"2OYCR4A2XT4N","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"pith_short_16","alias_value":"2OYCR4A2XT4N27F4","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"pith_short_8","alias_value":"2OYCR4A2","created_at":"2026-07-05T11:02:52Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:2OYCR4A2XT4N27F4XBGLHYNVDZ","target":"record","payload":{"canonical_record":{"source":{"id":"2505.09197","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.AP","submitted_at":"2025-05-14T07:18:06Z","cross_cats_sorted":["eess.IV"],"title_canon_sha256":"96c7792296e72e58e40b6de7a0cd6a8b82bc7e1da668d30d483a4468025211da","abstract_canon_sha256":"a0bcfaa38fa510053c06cb003382db54d9a8049bb319b63004e1da9887b3c01c"},"schema_version":"1.0"},"canonical_sha256":"d3b028f01abcf8dd7cbcb84cb3e1b51e7b889c5db6ebd18114e3af89f6d16af1","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:02:52.175506Z","signature_b64":"oHj1vmpmC++H0C6IU8qMz5pmmHieIevJDL6JcNmJJmvk47GJbh2t+F8VoxrCCSOOKy6XGWC/iUdYahHhNm44Dw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d3b028f01abcf8dd7cbcb84cb3e1b51e7b889c5db6ebd18114e3af89f6d16af1","last_reissued_at":"2026-07-05T11:02:52.174975Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:02:52.174975Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2505.09197","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:02:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1p/YJM8o+RMrIPjBIHrISYJuuDD/AYNam6eSCjXWM3C0nfWJcel5RTmWQ+RCQmciKdEAGIa+NDLXiDOE5QzODQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T21:57:49.368854Z"},"content_sha256":"cfa3df5d5cbc14138b635d5f60a546013393cce30ad8406913cb49aa6b978491","schema_version":"1.0","event_id":"sha256:cfa3df5d5cbc14138b635d5f60a546013393cce30ad8406913cb49aa6b978491"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:2OYCR4A2XT4N27F4XBGLHYNVDZ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Generalizing imaging biomarker repeatability studies using Bayesian inference: Applications in detecting heterogeneous treatment response in whole-body diffusion-weighted MRI of metastatic prostate cancer","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["eess.IV"],"primary_cat":"stat.AP","authors_text":"Antonio Candito, Chris Parker, David J Collins, Dow-Mu Koh, Johann de Bono, Konstantinos Zormpas-Petridis, Matthew D Blackledge, Nina Tunariu, Ricardo Donners","submitted_at":"2025-05-14T07:18:06Z","abstract_excerpt":"The assessment of imaging biomarkers is critical for advancing precision medicine and improving disease characterization. Despite the availability of methods to derive disease heterogeneity metrics in imaging studies, a robust framework for evaluating measurement uncertainty remains underdeveloped. To address this gap, we propose a novel Bayesian framework to assess the precision of disease heterogeneity measures in biomarker studies.\n  Our approach extends traditional methods for evaluating biomarker precision by providing greater flexibility in statistical assumptions and enabling the analys"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.09197","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.09197/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:02:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xpJ8e60I28ZuBuagFKS8ug1h01GAlGY79it7cMjA9MrhVVpV3CCuN7xB45jmhgsaqViHdEsNwm3Hwbm8c31vAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T21:57:49.369355Z"},"content_sha256":"48f923abda7e4529c47686239148ca51d267b8c2fe4cd1cba6aa2f2c6aeba5f7","schema_version":"1.0","event_id":"sha256:48f923abda7e4529c47686239148ca51d267b8c2fe4cd1cba6aa2f2c6aeba5f7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ/bundle.json","state_url":"https://pith.science/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-16T21:57:49Z","links":{"resolver":"https://pith.science/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ","bundle":"https://pith.science/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ/bundle.json","state":"https://pith.science/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2OYCR4A2XT4N27F4XBGLHYNVDZ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:2OYCR4A2XT4N27F4XBGLHYNVDZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a0bcfaa38fa510053c06cb003382db54d9a8049bb319b63004e1da9887b3c01c","cross_cats_sorted":["eess.IV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.AP","submitted_at":"2025-05-14T07:18:06Z","title_canon_sha256":"96c7792296e72e58e40b6de7a0cd6a8b82bc7e1da668d30d483a4468025211da"},"schema_version":"1.0","source":{"id":"2505.09197","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.09197","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"arxiv_version","alias_value":"2505.09197v1","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.09197","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"pith_short_12","alias_value":"2OYCR4A2XT4N","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"pith_short_16","alias_value":"2OYCR4A2XT4N27F4","created_at":"2026-07-05T11:02:52Z"},{"alias_kind":"pith_short_8","alias_value":"2OYCR4A2","created_at":"2026-07-05T11:02:52Z"}],"graph_snapshots":[{"event_id":"sha256:48f923abda7e4529c47686239148ca51d267b8c2fe4cd1cba6aa2f2c6aeba5f7","target":"graph","created_at":"2026-07-05T11:02:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.09197/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The assessment of imaging biomarkers is critical for advancing precision medicine and improving disease characterization. Despite the availability of methods to derive disease heterogeneity metrics in imaging studies, a robust framework for evaluating measurement uncertainty remains underdeveloped. To address this gap, we propose a novel Bayesian framework to assess the precision of disease heterogeneity measures in biomarker studies.\n  Our approach extends traditional methods for evaluating biomarker precision by providing greater flexibility in statistical assumptions and enabling the analys","authors_text":"Antonio Candito, Chris Parker, David J Collins, Dow-Mu Koh, Johann de Bono, Konstantinos Zormpas-Petridis, Matthew D Blackledge, Nina Tunariu, Ricardo Donners","cross_cats":["eess.IV"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.AP","submitted_at":"2025-05-14T07:18:06Z","title":"Generalizing imaging biomarker repeatability studies using Bayesian inference: Applications in detecting heterogeneous treatment response in whole-body diffusion-weighted MRI of metastatic prostate cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.09197","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cfa3df5d5cbc14138b635d5f60a546013393cce30ad8406913cb49aa6b978491","target":"record","created_at":"2026-07-05T11:02:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a0bcfaa38fa510053c06cb003382db54d9a8049bb319b63004e1da9887b3c01c","cross_cats_sorted":["eess.IV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.AP","submitted_at":"2025-05-14T07:18:06Z","title_canon_sha256":"96c7792296e72e58e40b6de7a0cd6a8b82bc7e1da668d30d483a4468025211da"},"schema_version":"1.0","source":{"id":"2505.09197","kind":"arxiv","version":1}},"canonical_sha256":"d3b028f01abcf8dd7cbcb84cb3e1b51e7b889c5db6ebd18114e3af89f6d16af1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d3b028f01abcf8dd7cbcb84cb3e1b51e7b889c5db6ebd18114e3af89f6d16af1","first_computed_at":"2026-07-05T11:02:52.174975Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:02:52.174975Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oHj1vmpmC++H0C6IU8qMz5pmmHieIevJDL6JcNmJJmvk47GJbh2t+F8VoxrCCSOOKy6XGWC/iUdYahHhNm44Dw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:02:52.175506Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.09197","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cfa3df5d5cbc14138b635d5f60a546013393cce30ad8406913cb49aa6b978491","sha256:48f923abda7e4529c47686239148ca51d267b8c2fe4cd1cba6aa2f2c6aeba5f7"],"state_sha256":"285e7f5e87cb61b124b4a3d941dfc6ea3b270d09677f57d86423a206b7473f31"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TCb6Sv+lo8hy6MohT5IcTfrCP5xroj2WA34FdVFzDZaAqvMVKmmLLLdHpMNa9XmUNUVQVvTtOGqbVYeGZxG1AA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-16T21:57:49.374408Z","bundle_sha256":"61c3b25a604f43edc91bca30ab14234c33dcf0cac131b0c742e5144bc797c1a9"}}