{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:2QTQX7UYLNPIX5ZHDSTZ3NYALQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b13e61b752c90f1a5640ce2413addfd293201dbc4fb33bb6cb0abdeadd023031","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-03-24T01:44:35Z","title_canon_sha256":"b3f4d751cf575a788e3a1a6ec0247ea96110a76d0a3d112291f8aa6c014ec432"},"schema_version":"1.0","source":{"id":"1703.08260","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1703.08260","created_at":"2026-05-18T00:16:32Z"},{"alias_kind":"arxiv_version","alias_value":"1703.08260v1","created_at":"2026-05-18T00:16:32Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1703.08260","created_at":"2026-05-18T00:16:32Z"},{"alias_kind":"pith_short_12","alias_value":"2QTQX7UYLNPI","created_at":"2026-05-18T12:30:55Z"},{"alias_kind":"pith_short_16","alias_value":"2QTQX7UYLNPIX5ZH","created_at":"2026-05-18T12:30:55Z"},{"alias_kind":"pith_short_8","alias_value":"2QTQX7UY","created_at":"2026-05-18T12:30:55Z"}],"graph_snapshots":[{"event_id":"sha256:88c50bf1a0e34431579ec91662cc69831a6dd4d07bb5acc467d75f0c5ce2d0f5","target":"graph","created_at":"2026-05-18T00:16:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Most human protein-coding genes can be transcribed into multiple possible distinct mRNA isoforms. These alternative splicing patterns encourage molecular diversity and dysregulation of isoform expression plays an important role in disease etiology. However, isoforms are difficult to characterize from short-read RNA-seq data because they share identical subsequences and exist in tissue- and sample-specific frequencies. Here, we develop BIISQ, a Bayesian nonparametric model to discover Isoforms and Individual Specific Quantification from RNA-seq data. BIISQ does not require known isoform referen","authors_text":"Athma A Pai, Barbara E Engelhardt, Bianca Dumitrascu, Derek Aguiar, Fantine Mordelet, Li-Fang Cheng","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-03-24T01:44:35Z","title":"BIISQ: Bayesian nonparametric discovery of Isoforms and Individual Specific Quantification"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1703.08260","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:909e008159489d64e6d4a2d0dd3d5a695b4123a6a31f6f9f9def3cfa713e5ac4","target":"record","created_at":"2026-05-18T00:16:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b13e61b752c90f1a5640ce2413addfd293201dbc4fb33bb6cb0abdeadd023031","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-03-24T01:44:35Z","title_canon_sha256":"b3f4d751cf575a788e3a1a6ec0247ea96110a76d0a3d112291f8aa6c014ec432"},"schema_version":"1.0","source":{"id":"1703.08260","kind":"arxiv","version":1}},"canonical_sha256":"d4270bfe985b5e8bf7271ca79db7005c35dde00784407b2cd961547a36e200df","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d4270bfe985b5e8bf7271ca79db7005c35dde00784407b2cd961547a36e200df","first_computed_at":"2026-05-18T00:16:32.300420Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:16:32.300420Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EiCOwR3BTtemdJE9RF/pUeqTwJlc4aFIf11dYmIAUczeL1i9AIddohoqT3nKhBci1RJURduiC9cHYBFGlAIhCg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:16:32.300850Z","signed_message":"canonical_sha256_bytes"},"source_id":"1703.08260","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:909e008159489d64e6d4a2d0dd3d5a695b4123a6a31f6f9f9def3cfa713e5ac4","sha256:88c50bf1a0e34431579ec91662cc69831a6dd4d07bb5acc467d75f0c5ce2d0f5"],"state_sha256":"60b2b8087bbc105385bea453e3de64ff93a6bef905faaeef1ab06ec6f9c7154d"}