{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:2T5GWWQP5ELVXOJUSHGCUUA453","short_pith_number":"pith:2T5GWWQP","canonical_record":{"source":{"id":"1408.3236","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-08-14T09:58:51Z","cross_cats_sorted":[],"title_canon_sha256":"6ab7a87c1f7672dfc4ad8f2294367be100270f13c5bf8853f4d10c017f97fc54","abstract_canon_sha256":"b2eb4e94947271312dbae0dd7a76dfa4e290266ba9aa0d247484f8d407791df9"},"schema_version":"1.0"},"canonical_sha256":"d4fa6b5a0fe9175bb93491cc2a501ceec3cc46246d3152a8b74b30a739f76f6e","source":{"kind":"arxiv","id":"1408.3236","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.3236","created_at":"2026-05-18T01:20:47Z"},{"alias_kind":"arxiv_version","alias_value":"1408.3236v1","created_at":"2026-05-18T01:20:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.3236","created_at":"2026-05-18T01:20:47Z"},{"alias_kind":"pith_short_12","alias_value":"2T5GWWQP5ELV","created_at":"2026-05-18T12:28:11Z"},{"alias_kind":"pith_short_16","alias_value":"2T5GWWQP5ELVXOJU","created_at":"2026-05-18T12:28:11Z"},{"alias_kind":"pith_short_8","alias_value":"2T5GWWQP","created_at":"2026-05-18T12:28:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:2T5GWWQP5ELVXOJUSHGCUUA453","target":"record","payload":{"canonical_record":{"source":{"id":"1408.3236","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-08-14T09:58:51Z","cross_cats_sorted":[],"title_canon_sha256":"6ab7a87c1f7672dfc4ad8f2294367be100270f13c5bf8853f4d10c017f97fc54","abstract_canon_sha256":"b2eb4e94947271312dbae0dd7a76dfa4e290266ba9aa0d247484f8d407791df9"},"schema_version":"1.0"},"canonical_sha256":"d4fa6b5a0fe9175bb93491cc2a501ceec3cc46246d3152a8b74b30a739f76f6e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:20:47.447845Z","signature_b64":"vmekJSla6w8jaCF5HJNdHtYy2V5gob96MyRdvtlMQ2VbUN3e2Oq50st2XN6Ad4jru4kDtzlRV3yTdA7AI4wgBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d4fa6b5a0fe9175bb93491cc2a501ceec3cc46246d3152a8b74b30a739f76f6e","last_reissued_at":"2026-05-18T01:20:47.447383Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:20:47.447383Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1408.3236","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:20:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8GwtV+fYJb3UNt1/i50lTLsMTW7aetVR68A7QBEMHDlOAfS5+36WekkaMHM5+sX/96NMxIFgaLQluefjEmBFDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T19:48:48.425446Z"},"content_sha256":"579856d88103e00fb736c649c95755fe8d18e25e7a05fe7d5fe33052fd02ac0c","schema_version":"1.0","event_id":"sha256:579856d88103e00fb736c649c95755fe8d18e25e7a05fe7d5fe33052fd02ac0c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:2T5GWWQP5ELVXOJUSHGCUUA453","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The degenerative evolution from multicellularity to unicellularity during cancer","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Fangqin Lin, Han Chen, Xionglei He","submitted_at":"2014-08-14T09:58:51Z","abstract_excerpt":"Theoretical reasoning suggests that human cancer may result from knocking down the genetic constraints evolved for maintenance of the metazoan multicellularity, which, however, requires a critical test. Using xenograft-based experimental evolution we characterized for the first time the full life history from initiation to metastasis of a tumor at the genomic and transcriptomic levels, and observed metastasis-driving positive selection for generally loss-of-function mutations on a set of multicellularity-related genes, which is further supported by large-scale exome data of clinical tumor samp"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.3236","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:20:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YeoGXTc6PPV1jLgSud7WtMP3ZOXUtXEZTRlVGGZm7kykhyctrQjIxOxNrsQgL/vdNNjDsz82gRq2dOYyek/pBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T19:48:48.426140Z"},"content_sha256":"0514fb913c44b85db06e56243d754d9131b96d6134d127a820c48642ba964525","schema_version":"1.0","event_id":"sha256:0514fb913c44b85db06e56243d754d9131b96d6134d127a820c48642ba964525"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/2T5GWWQP5ELVXOJUSHGCUUA453/bundle.json","state_url":"https://pith.science/pith/2T5GWWQP5ELVXOJUSHGCUUA453/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/2T5GWWQP5ELVXOJUSHGCUUA453/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T19:48:48Z","links":{"resolver":"https://pith.science/pith/2T5GWWQP5ELVXOJUSHGCUUA453","bundle":"https://pith.science/pith/2T5GWWQP5ELVXOJUSHGCUUA453/bundle.json","state":"https://pith.science/pith/2T5GWWQP5ELVXOJUSHGCUUA453/state.json","well_known_bundle":"https://pith.science/.well-known/pith/2T5GWWQP5ELVXOJUSHGCUUA453/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:2T5GWWQP5ELVXOJUSHGCUUA453","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b2eb4e94947271312dbae0dd7a76dfa4e290266ba9aa0d247484f8d407791df9","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-08-14T09:58:51Z","title_canon_sha256":"6ab7a87c1f7672dfc4ad8f2294367be100270f13c5bf8853f4d10c017f97fc54"},"schema_version":"1.0","source":{"id":"1408.3236","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.3236","created_at":"2026-05-18T01:20:47Z"},{"alias_kind":"arxiv_version","alias_value":"1408.3236v1","created_at":"2026-05-18T01:20:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.3236","created_at":"2026-05-18T01:20:47Z"},{"alias_kind":"pith_short_12","alias_value":"2T5GWWQP5ELV","created_at":"2026-05-18T12:28:11Z"},{"alias_kind":"pith_short_16","alias_value":"2T5GWWQP5ELVXOJU","created_at":"2026-05-18T12:28:11Z"},{"alias_kind":"pith_short_8","alias_value":"2T5GWWQP","created_at":"2026-05-18T12:28:11Z"}],"graph_snapshots":[{"event_id":"sha256:0514fb913c44b85db06e56243d754d9131b96d6134d127a820c48642ba964525","target":"graph","created_at":"2026-05-18T01:20:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Theoretical reasoning suggests that human cancer may result from knocking down the genetic constraints evolved for maintenance of the metazoan multicellularity, which, however, requires a critical test. Using xenograft-based experimental evolution we characterized for the first time the full life history from initiation to metastasis of a tumor at the genomic and transcriptomic levels, and observed metastasis-driving positive selection for generally loss-of-function mutations on a set of multicellularity-related genes, which is further supported by large-scale exome data of clinical tumor samp","authors_text":"Fangqin Lin, Han Chen, Xionglei He","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-08-14T09:58:51Z","title":"The degenerative evolution from multicellularity to unicellularity during cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.3236","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:579856d88103e00fb736c649c95755fe8d18e25e7a05fe7d5fe33052fd02ac0c","target":"record","created_at":"2026-05-18T01:20:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b2eb4e94947271312dbae0dd7a76dfa4e290266ba9aa0d247484f8d407791df9","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-08-14T09:58:51Z","title_canon_sha256":"6ab7a87c1f7672dfc4ad8f2294367be100270f13c5bf8853f4d10c017f97fc54"},"schema_version":"1.0","source":{"id":"1408.3236","kind":"arxiv","version":1}},"canonical_sha256":"d4fa6b5a0fe9175bb93491cc2a501ceec3cc46246d3152a8b74b30a739f76f6e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d4fa6b5a0fe9175bb93491cc2a501ceec3cc46246d3152a8b74b30a739f76f6e","first_computed_at":"2026-05-18T01:20:47.447383Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:20:47.447383Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vmekJSla6w8jaCF5HJNdHtYy2V5gob96MyRdvtlMQ2VbUN3e2Oq50st2XN6Ad4jru4kDtzlRV3yTdA7AI4wgBg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:20:47.447845Z","signed_message":"canonical_sha256_bytes"},"source_id":"1408.3236","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:579856d88103e00fb736c649c95755fe8d18e25e7a05fe7d5fe33052fd02ac0c","sha256:0514fb913c44b85db06e56243d754d9131b96d6134d127a820c48642ba964525"],"state_sha256":"71d75ff5c44b944c627121f7ff637ce4189f7fa9b548d650e41e99f1d7d54f80"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fbfG3uQALRvaUVKK8YprNn3LXGT9XXesloBTjmlLQwO3rc8Fc995OfebHdfqvJQEY0wt91G1lb+N4iOsG2jnAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T19:48:48.429664Z","bundle_sha256":"87c51276e724fb7b320ec9be9ed4fef08d5c99ae06cf7c4449e1df36b0baa5fa"}}