{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:33RGQ4HTRINKH4HATUVZ5OAPA5","short_pith_number":"pith:33RGQ4HT","canonical_record":{"source":{"id":"2109.05709","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2021-09-13T05:07:35Z","cross_cats_sorted":[],"title_canon_sha256":"8f542081c2e729b6898c583a93c793a20d9e3c588d857b8a05286796da3c3c2b","abstract_canon_sha256":"6e147e387896814811511c37bba51e12ccbb3276c507cb5feb2ab67c1e89c9a1"},"schema_version":"1.0"},"canonical_sha256":"dee26870f38a1aa3f0e09d2b9eb80f0740a1187e11d3bf11b0e3ef13ae88eb67","source":{"kind":"arxiv","id":"2109.05709","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.05709","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"arxiv_version","alias_value":"2109.05709v1","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.05709","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"pith_short_12","alias_value":"33RGQ4HTRINK","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"pith_short_16","alias_value":"33RGQ4HTRINKH4HA","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"pith_short_8","alias_value":"33RGQ4HT","created_at":"2026-07-05T03:13:41Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:33RGQ4HTRINKH4HATUVZ5OAPA5","target":"record","payload":{"canonical_record":{"source":{"id":"2109.05709","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2021-09-13T05:07:35Z","cross_cats_sorted":[],"title_canon_sha256":"8f542081c2e729b6898c583a93c793a20d9e3c588d857b8a05286796da3c3c2b","abstract_canon_sha256":"6e147e387896814811511c37bba51e12ccbb3276c507cb5feb2ab67c1e89c9a1"},"schema_version":"1.0"},"canonical_sha256":"dee26870f38a1aa3f0e09d2b9eb80f0740a1187e11d3bf11b0e3ef13ae88eb67","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:13:41.539456Z","signature_b64":"6nRC6wg+A0NQXCadUGA8ILVnP6XW18ltMjGg161GK6GWdPfzHi6jbjAGrCeFUhcroZHbvgu5Qu12l3dwQF2rDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"dee26870f38a1aa3f0e09d2b9eb80f0740a1187e11d3bf11b0e3ef13ae88eb67","last_reissued_at":"2026-07-05T03:13:41.539007Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:13:41.539007Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2109.05709","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:13:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pzsJP+Yl62WfnMptBcqNtcTYenMoFar7oLLKb2pG4rweRLiFmGM0VBuN25lqqr8oGoh4OEexl5cf4wwLu62iAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-20T20:01:27.870374Z"},"content_sha256":"5698026eae15726fef457a12706747de641f88fa999b1c0608b9d08554d6fda8","schema_version":"1.0","event_id":"sha256:5698026eae15726fef457a12706747de641f88fa999b1c0608b9d08554d6fda8"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:33RGQ4HTRINKH4HATUVZ5OAPA5","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Thermostatic Hyperthermia with Non-invasive Temperature Monitoring through Speed of Sound Imaging","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Paul Carson, Yuan Jie, Yuchan Wang, Yuening Wang","submitted_at":"2021-09-13T05:07:35Z","abstract_excerpt":"Hyperthermia therapy (HT) is used to treat diseases through heating of high temperature usually in conjunction with some other medical therapeutics like chemotherapy and radiotherapy. In this study, we propose a promising thermostatic hyperthermia method that uses high-intensity focused ultrasound (HIFU) for clinical tumor treatment combined with diagnostic ultrasound image guidance and non-invasive temperature monitoring through the speed of sound (SOS) imaging. HIFU heating is realized by a ring ultrasound transducer array with 256 elements. The inner structure information of thigh tissue is"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.05709","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2109.05709/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:13:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IM4AVObD8Orq31TY5R07MUi9EBusfmcuA0YryldCvkZ/sPfaCa3uY1M5gfCBKDUoXtdhf8oWjSHA+PUlQk7oBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-20T20:01:27.871021Z"},"content_sha256":"c6606faa9a952754a6c236d901c6af1ce77616538f2b5884e589f600504ccf53","schema_version":"1.0","event_id":"sha256:c6606faa9a952754a6c236d901c6af1ce77616538f2b5884e589f600504ccf53"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/33RGQ4HTRINKH4HATUVZ5OAPA5/bundle.json","state_url":"https://pith.science/pith/33RGQ4HTRINKH4HATUVZ5OAPA5/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/33RGQ4HTRINKH4HATUVZ5OAPA5/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-20T20:01:27Z","links":{"resolver":"https://pith.science/pith/33RGQ4HTRINKH4HATUVZ5OAPA5","bundle":"https://pith.science/pith/33RGQ4HTRINKH4HATUVZ5OAPA5/bundle.json","state":"https://pith.science/pith/33RGQ4HTRINKH4HATUVZ5OAPA5/state.json","well_known_bundle":"https://pith.science/.well-known/pith/33RGQ4HTRINKH4HATUVZ5OAPA5/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:33RGQ4HTRINKH4HATUVZ5OAPA5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6e147e387896814811511c37bba51e12ccbb3276c507cb5feb2ab67c1e89c9a1","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2021-09-13T05:07:35Z","title_canon_sha256":"8f542081c2e729b6898c583a93c793a20d9e3c588d857b8a05286796da3c3c2b"},"schema_version":"1.0","source":{"id":"2109.05709","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.05709","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"arxiv_version","alias_value":"2109.05709v1","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.05709","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"pith_short_12","alias_value":"33RGQ4HTRINK","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"pith_short_16","alias_value":"33RGQ4HTRINKH4HA","created_at":"2026-07-05T03:13:41Z"},{"alias_kind":"pith_short_8","alias_value":"33RGQ4HT","created_at":"2026-07-05T03:13:41Z"}],"graph_snapshots":[{"event_id":"sha256:c6606faa9a952754a6c236d901c6af1ce77616538f2b5884e589f600504ccf53","target":"graph","created_at":"2026-07-05T03:13:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2109.05709/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Hyperthermia therapy (HT) is used to treat diseases through heating of high temperature usually in conjunction with some other medical therapeutics like chemotherapy and radiotherapy. In this study, we propose a promising thermostatic hyperthermia method that uses high-intensity focused ultrasound (HIFU) for clinical tumor treatment combined with diagnostic ultrasound image guidance and non-invasive temperature monitoring through the speed of sound (SOS) imaging. HIFU heating is realized by a ring ultrasound transducer array with 256 elements. The inner structure information of thigh tissue is","authors_text":"Paul Carson, Yuan Jie, Yuchan Wang, Yuening Wang","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2021-09-13T05:07:35Z","title":"Thermostatic Hyperthermia with Non-invasive Temperature Monitoring through Speed of Sound Imaging"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.05709","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5698026eae15726fef457a12706747de641f88fa999b1c0608b9d08554d6fda8","target":"record","created_at":"2026-07-05T03:13:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6e147e387896814811511c37bba51e12ccbb3276c507cb5feb2ab67c1e89c9a1","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2021-09-13T05:07:35Z","title_canon_sha256":"8f542081c2e729b6898c583a93c793a20d9e3c588d857b8a05286796da3c3c2b"},"schema_version":"1.0","source":{"id":"2109.05709","kind":"arxiv","version":1}},"canonical_sha256":"dee26870f38a1aa3f0e09d2b9eb80f0740a1187e11d3bf11b0e3ef13ae88eb67","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"dee26870f38a1aa3f0e09d2b9eb80f0740a1187e11d3bf11b0e3ef13ae88eb67","first_computed_at":"2026-07-05T03:13:41.539007Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:13:41.539007Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"6nRC6wg+A0NQXCadUGA8ILVnP6XW18ltMjGg161GK6GWdPfzHi6jbjAGrCeFUhcroZHbvgu5Qu12l3dwQF2rDw==","signature_status":"signed_v1","signed_at":"2026-07-05T03:13:41.539456Z","signed_message":"canonical_sha256_bytes"},"source_id":"2109.05709","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5698026eae15726fef457a12706747de641f88fa999b1c0608b9d08554d6fda8","sha256:c6606faa9a952754a6c236d901c6af1ce77616538f2b5884e589f600504ccf53"],"state_sha256":"a76c3d5c12d0cfb3a934f28d1919e6671d241eac5e8506f23509e86f7293b536"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"hlAtWfQzI+9jLY8i+07MePKPE9i02b68HBFKx0hJDWcZIGKKoCBabBB/sJLeoMzsQiJfL3i8T6NgbYnK4ECEAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-20T20:01:27.876199Z","bundle_sha256":"392cb1c1c7903f972706a9d87b8e0e2b09e0007bce5e333a37d744ef1882a0db"}}