{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:3DK57GYW6NVM6FPLG5SCBCCKLP","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8f0ac252084babaa7f0dd1990018523d58ed2be1f727d92019e036c91bbcae37","cross_cats_sorted":["stat.ME","stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2016-03-14T23:13:45Z","title_canon_sha256":"29a9008a0ff13e69417b2f403496e5481c12673cadb61ba92eeef12e6e680f48"},"schema_version":"1.0","source":{"id":"1603.04500","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1603.04500","created_at":"2026-05-18T01:19:04Z"},{"alias_kind":"arxiv_version","alias_value":"1603.04500v1","created_at":"2026-05-18T01:19:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1603.04500","created_at":"2026-05-18T01:19:04Z"},{"alias_kind":"pith_short_12","alias_value":"3DK57GYW6NVM","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_16","alias_value":"3DK57GYW6NVM6FPL","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_8","alias_value":"3DK57GYW","created_at":"2026-05-18T12:29:55Z"}],"graph_snapshots":[{"event_id":"sha256:3bc444abbfd49553be5123c09b385e2ef8e8d997996597a9ac9e88a8d9c929ef","target":"graph","created_at":"2026-05-18T01:19:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A common problem in Phase II clinical trials is the comparison of dose response curves corresponding to different treatment groups. If the effect of the dose level is described by parametric regression models and the treatments differ in the administration frequency (but not in the sort of drug) a reasonable assumption is that the regression models for the different treatments share common parameters. This paper develops optimal design theory for the comparison of different regression models with common parameters. We derive upper bounds on the number of support points of admissible designs, a","authors_text":"Bj\\\"orn Bornkamp, Chrystel Feller, Georgina Bermann, Holger Dette, Kirsten Schorning","cross_cats":["stat.ME","stat.TH"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2016-03-14T23:13:45Z","title":"Optimal designs for dose response curves with common parameters"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1603.04500","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a25976f7e8a37bf6a551d5791e41589f6ae44e111b63217140598fb7d6ff87f8","target":"record","created_at":"2026-05-18T01:19:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8f0ac252084babaa7f0dd1990018523d58ed2be1f727d92019e036c91bbcae37","cross_cats_sorted":["stat.ME","stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2016-03-14T23:13:45Z","title_canon_sha256":"29a9008a0ff13e69417b2f403496e5481c12673cadb61ba92eeef12e6e680f48"},"schema_version":"1.0","source":{"id":"1603.04500","kind":"arxiv","version":1}},"canonical_sha256":"d8d5df9b16f36acf15eb376420884a5bfaf85f24d31b1bfd2756dbffa330890e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d8d5df9b16f36acf15eb376420884a5bfaf85f24d31b1bfd2756dbffa330890e","first_computed_at":"2026-05-18T01:19:04.783861Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:19:04.783861Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"GTtB042ZmY0azSgeh3jF3j3/j0t7mThXbaNuSrUgln2lE00rN4V+jS1cfkbUbKQMZOy9RWAjNYWSlfoP26vKDw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:19:04.784308Z","signed_message":"canonical_sha256_bytes"},"source_id":"1603.04500","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a25976f7e8a37bf6a551d5791e41589f6ae44e111b63217140598fb7d6ff87f8","sha256:3bc444abbfd49553be5123c09b385e2ef8e8d997996597a9ac9e88a8d9c929ef"],"state_sha256":"079081fa780a9928c9fefe9e5448e88c277732b31d3d63c729700d924fe85bf9"}