{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:3HLRQQXHHSPZPOU63BKJMSSLZ6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"14e6ab598e0512be4ebe2ccda23fa0d9079869a120d73c62c5a61531f8dda1c7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-01-14T18:56:50Z","title_canon_sha256":"7670cb5153c2ad023576398712aca1aede22d6d067f3a854a774e24551698962"},"schema_version":"1.0","source":{"id":"1301.3095","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1301.3095","created_at":"2026-05-18T01:00:20Z"},{"alias_kind":"arxiv_version","alias_value":"1301.3095v1","created_at":"2026-05-18T01:00:20Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1301.3095","created_at":"2026-05-18T01:00:20Z"},{"alias_kind":"pith_short_12","alias_value":"3HLRQQXHHSPZ","created_at":"2026-05-18T12:27:32Z"},{"alias_kind":"pith_short_16","alias_value":"3HLRQQXHHSPZPOU6","created_at":"2026-05-18T12:27:32Z"},{"alias_kind":"pith_short_8","alias_value":"3HLRQQXH","created_at":"2026-05-18T12:27:32Z"}],"graph_snapshots":[{"event_id":"sha256:37db55642ce05e0095213a77313eaeb91260b42f50cb38f8b321e4bad11b2831","target":"graph","created_at":"2026-05-18T01:00:20Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrPC undergoes in the conversion process to a self-replicating state is still not fully understood. The ordered C-terminus of PrPC proteins has three helices (H1, H2, and H3). Here, we use the Statistical Coupling Analysis (SCA) to infer co-variations at various locations using a family of evolutionarily related sequences, and the response of mouse and human PrPCs to mechanical force to decipher the initiatio","authors_text":"Devarajan Thirumalai, Jie Chen","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-01-14T18:56:50Z","title":"Helices 2 and 3 are the initiation sites in the PrPc -> PrPsc transition"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1301.3095","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:644e8585a663c50d54647da6a357bb56d049cff3a443839bad687b4d9c7bd301","target":"record","created_at":"2026-05-18T01:00:20Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"14e6ab598e0512be4ebe2ccda23fa0d9079869a120d73c62c5a61531f8dda1c7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-01-14T18:56:50Z","title_canon_sha256":"7670cb5153c2ad023576398712aca1aede22d6d067f3a854a774e24551698962"},"schema_version":"1.0","source":{"id":"1301.3095","kind":"arxiv","version":1}},"canonical_sha256":"d9d71842e73c9f97ba9ed854964a4bcf826c8eee8ae7aa904c612a3310242fa8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d9d71842e73c9f97ba9ed854964a4bcf826c8eee8ae7aa904c612a3310242fa8","first_computed_at":"2026-05-18T01:00:20.903334Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:00:20.903334Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"en7tWYqzrgN7GkzLQoSRGWYt1F3DR728vTqJjvGPsCFCOkMML2r20eB0Rdct3P+gxCPuhfJH5/I8MSl81ZvBBA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:00:20.903868Z","signed_message":"canonical_sha256_bytes"},"source_id":"1301.3095","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:644e8585a663c50d54647da6a357bb56d049cff3a443839bad687b4d9c7bd301","sha256:37db55642ce05e0095213a77313eaeb91260b42f50cb38f8b321e4bad11b2831"],"state_sha256":"c1eaeec720b5de68b896f2f761761ca860377f1202852aff1737f654492fffb0"}