{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:3HTPO5HDTIQPHT7QN4KNLNFX42","short_pith_number":"pith:3HTPO5HD","schema_version":"1.0","canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","source":{"kind":"arxiv","id":"1612.08763","version":3},"attestation_state":"computed","paper":{"title":"The structure of MESSI biological systems","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.AG"],"primary_cat":"q-bio.MN","authors_text":"Alicia Dickenstein, Mercedes P\\'erez Mill\\'an","submitted_at":"2016-12-27T22:09:23Z","abstract_excerpt":"We introduce a general framework for biological systems, called MESSI systems, that describe Modifications of type Enzyme-Substrate or Swap with Intermediates, and we prove general results based on the network structure. Many post-translational modification networks are MESSI systems. For example: the motifs in [Feliu and Wiuf (2012a)], sequential distributive and processive multisite phosphorylation networks, most of the examples in [Angeli et al. (2007)], phosphorylation cascades, two component systems as in [Kothamachu et al. (2015)], the bacterial EnvZ/OmpR network in [Shinar and Feinberg "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1612.08763","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-27T22:09:23Z","cross_cats_sorted":["math.AG"],"title_canon_sha256":"8be29ccff5f65ef8ffc23046bc51d8e3dadc6c435c3aecc23035df7c864abd8b","abstract_canon_sha256":"44d1165fad3391d42eb576915addffefcd0605ddc56b3bdd7f1be221908fc2df"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:16:45.597293Z","signature_b64":"Zgn8yLVPZ9VlXtr4Gc0CmGYoTBsCazfX61+jzqtmFyQIQLiPixQsme+HTQcZySxNybzets7gvyqPzoX0RJrhDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","last_reissued_at":"2026-05-18T00:16:45.596792Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:16:45.596792Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The structure of MESSI biological systems","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.AG"],"primary_cat":"q-bio.MN","authors_text":"Alicia Dickenstein, Mercedes P\\'erez Mill\\'an","submitted_at":"2016-12-27T22:09:23Z","abstract_excerpt":"We introduce a general framework for biological systems, called MESSI systems, that describe Modifications of type Enzyme-Substrate or Swap with Intermediates, and we prove general results based on the network structure. Many post-translational modification networks are MESSI systems. For example: the motifs in [Feliu and Wiuf (2012a)], sequential distributive and processive multisite phosphorylation networks, most of the examples in [Angeli et al. (2007)], phosphorylation cascades, two component systems as in [Kothamachu et al. (2015)], the bacterial EnvZ/OmpR network in [Shinar and Feinberg "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.08763","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1612.08763","created_at":"2026-05-18T00:16:45.596861+00:00"},{"alias_kind":"arxiv_version","alias_value":"1612.08763v3","created_at":"2026-05-18T00:16:45.596861+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.08763","created_at":"2026-05-18T00:16:45.596861+00:00"},{"alias_kind":"pith_short_12","alias_value":"3HTPO5HDTIQP","created_at":"2026-05-18T12:29:55.572404+00:00"},{"alias_kind":"pith_short_16","alias_value":"3HTPO5HDTIQPHT7Q","created_at":"2026-05-18T12:29:55.572404+00:00"},{"alias_kind":"pith_short_8","alias_value":"3HTPO5HD","created_at":"2026-05-18T12:29:55.572404+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42","json":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42.json","graph_json":"https://pith.science/api/pith-number/3HTPO5HDTIQPHT7QN4KNLNFX42/graph.json","events_json":"https://pith.science/api/pith-number/3HTPO5HDTIQPHT7QN4KNLNFX42/events.json","paper":"https://pith.science/paper/3HTPO5HD"},"agent_actions":{"view_html":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42","download_json":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42.json","view_paper":"https://pith.science/paper/3HTPO5HD","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1612.08763&json=true","fetch_graph":"https://pith.science/api/pith-number/3HTPO5HDTIQPHT7QN4KNLNFX42/graph.json","fetch_events":"https://pith.science/api/pith-number/3HTPO5HDTIQPHT7QN4KNLNFX42/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/action/timestamp_anchor","attest_storage":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/action/storage_attestation","attest_author":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/action/author_attestation","sign_citation":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/action/citation_signature","submit_replication":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/action/replication_record"}},"created_at":"2026-05-18T00:16:45.596861+00:00","updated_at":"2026-05-18T00:16:45.596861+00:00"}