{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:3HTPO5HDTIQPHT7QN4KNLNFX42","short_pith_number":"pith:3HTPO5HD","canonical_record":{"source":{"id":"1612.08763","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-27T22:09:23Z","cross_cats_sorted":["math.AG"],"title_canon_sha256":"8be29ccff5f65ef8ffc23046bc51d8e3dadc6c435c3aecc23035df7c864abd8b","abstract_canon_sha256":"44d1165fad3391d42eb576915addffefcd0605ddc56b3bdd7f1be221908fc2df"},"schema_version":"1.0"},"canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","source":{"kind":"arxiv","id":"1612.08763","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1612.08763","created_at":"2026-05-18T00:16:45Z"},{"alias_kind":"arxiv_version","alias_value":"1612.08763v3","created_at":"2026-05-18T00:16:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.08763","created_at":"2026-05-18T00:16:45Z"},{"alias_kind":"pith_short_12","alias_value":"3HTPO5HDTIQP","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_16","alias_value":"3HTPO5HDTIQPHT7Q","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_8","alias_value":"3HTPO5HD","created_at":"2026-05-18T12:29:55Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:3HTPO5HDTIQPHT7QN4KNLNFX42","target":"record","payload":{"canonical_record":{"source":{"id":"1612.08763","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-27T22:09:23Z","cross_cats_sorted":["math.AG"],"title_canon_sha256":"8be29ccff5f65ef8ffc23046bc51d8e3dadc6c435c3aecc23035df7c864abd8b","abstract_canon_sha256":"44d1165fad3391d42eb576915addffefcd0605ddc56b3bdd7f1be221908fc2df"},"schema_version":"1.0"},"canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:16:45.597293Z","signature_b64":"Zgn8yLVPZ9VlXtr4Gc0CmGYoTBsCazfX61+jzqtmFyQIQLiPixQsme+HTQcZySxNybzets7gvyqPzoX0RJrhDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","last_reissued_at":"2026-05-18T00:16:45.596792Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:16:45.596792Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1612.08763","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:16:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HbLRgEddMrEv1vqfQ6jLFqwBvkSWUMegshhDJJ6VVOonu70fPmjGEikKcX4lHatJia/hspinYSpoNyPurXhsDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T20:45:07.680469Z"},"content_sha256":"d6c1ce6db9b5f7b34632d6768f2767fbf73ceccbeb7d0976069411370cd26fc2","schema_version":"1.0","event_id":"sha256:d6c1ce6db9b5f7b34632d6768f2767fbf73ceccbeb7d0976069411370cd26fc2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:3HTPO5HDTIQPHT7QN4KNLNFX42","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The structure of MESSI biological systems","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.AG"],"primary_cat":"q-bio.MN","authors_text":"Alicia Dickenstein, Mercedes P\\'erez Mill\\'an","submitted_at":"2016-12-27T22:09:23Z","abstract_excerpt":"We introduce a general framework for biological systems, called MESSI systems, that describe Modifications of type Enzyme-Substrate or Swap with Intermediates, and we prove general results based on the network structure. Many post-translational modification networks are MESSI systems. For example: the motifs in [Feliu and Wiuf (2012a)], sequential distributive and processive multisite phosphorylation networks, most of the examples in [Angeli et al. (2007)], phosphorylation cascades, two component systems as in [Kothamachu et al. (2015)], the bacterial EnvZ/OmpR network in [Shinar and Feinberg "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.08763","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:16:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"GZ6Rbfnz6ZSy1ZyQHtuC+x7gzgq01zmtLRQAq+WGFtAg0pUorG6nAnLqKLQblOv1t1SV6dPQLv2RSWS6AfnXCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T20:45:07.681172Z"},"content_sha256":"9138d75dcd8303c3c5b1d1ccd0c19806073978969bb5887c8ffc8bc8ee1bd5ff","schema_version":"1.0","event_id":"sha256:9138d75dcd8303c3c5b1d1ccd0c19806073978969bb5887c8ffc8bc8ee1bd5ff"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/bundle.json","state_url":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T20:45:07Z","links":{"resolver":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42","bundle":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/bundle.json","state":"https://pith.science/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/state.json","well_known_bundle":"https://pith.science/.well-known/pith/3HTPO5HDTIQPHT7QN4KNLNFX42/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:3HTPO5HDTIQPHT7QN4KNLNFX42","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"44d1165fad3391d42eb576915addffefcd0605ddc56b3bdd7f1be221908fc2df","cross_cats_sorted":["math.AG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-27T22:09:23Z","title_canon_sha256":"8be29ccff5f65ef8ffc23046bc51d8e3dadc6c435c3aecc23035df7c864abd8b"},"schema_version":"1.0","source":{"id":"1612.08763","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1612.08763","created_at":"2026-05-18T00:16:45Z"},{"alias_kind":"arxiv_version","alias_value":"1612.08763v3","created_at":"2026-05-18T00:16:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.08763","created_at":"2026-05-18T00:16:45Z"},{"alias_kind":"pith_short_12","alias_value":"3HTPO5HDTIQP","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_16","alias_value":"3HTPO5HDTIQPHT7Q","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_8","alias_value":"3HTPO5HD","created_at":"2026-05-18T12:29:55Z"}],"graph_snapshots":[{"event_id":"sha256:9138d75dcd8303c3c5b1d1ccd0c19806073978969bb5887c8ffc8bc8ee1bd5ff","target":"graph","created_at":"2026-05-18T00:16:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We introduce a general framework for biological systems, called MESSI systems, that describe Modifications of type Enzyme-Substrate or Swap with Intermediates, and we prove general results based on the network structure. Many post-translational modification networks are MESSI systems. For example: the motifs in [Feliu and Wiuf (2012a)], sequential distributive and processive multisite phosphorylation networks, most of the examples in [Angeli et al. (2007)], phosphorylation cascades, two component systems as in [Kothamachu et al. (2015)], the bacterial EnvZ/OmpR network in [Shinar and Feinberg ","authors_text":"Alicia Dickenstein, Mercedes P\\'erez Mill\\'an","cross_cats":["math.AG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-27T22:09:23Z","title":"The structure of MESSI biological systems"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.08763","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d6c1ce6db9b5f7b34632d6768f2767fbf73ceccbeb7d0976069411370cd26fc2","target":"record","created_at":"2026-05-18T00:16:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"44d1165fad3391d42eb576915addffefcd0605ddc56b3bdd7f1be221908fc2df","cross_cats_sorted":["math.AG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-27T22:09:23Z","title_canon_sha256":"8be29ccff5f65ef8ffc23046bc51d8e3dadc6c435c3aecc23035df7c864abd8b"},"schema_version":"1.0","source":{"id":"1612.08763","kind":"arxiv","version":3}},"canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"d9e6f774e39a20f3cff06f14d5b4b7e69eacda093630e8885cd09d5c2693e6d5","first_computed_at":"2026-05-18T00:16:45.596792Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:16:45.596792Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Zgn8yLVPZ9VlXtr4Gc0CmGYoTBsCazfX61+jzqtmFyQIQLiPixQsme+HTQcZySxNybzets7gvyqPzoX0RJrhDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:16:45.597293Z","signed_message":"canonical_sha256_bytes"},"source_id":"1612.08763","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d6c1ce6db9b5f7b34632d6768f2767fbf73ceccbeb7d0976069411370cd26fc2","sha256:9138d75dcd8303c3c5b1d1ccd0c19806073978969bb5887c8ffc8bc8ee1bd5ff"],"state_sha256":"bb9fb0798e1206a86d0510c4b4869ab58dc78800167e5c05b3c7702040c4d8ef"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DLQo+4eJV9hPa3xLUWPHoH3kDDhnaUhmPfwSmqhrf9ubd6WDMOzc9ifMXKFEygSXnzTHqE1+ix6a7tYgEVLVAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T20:45:07.684960Z","bundle_sha256":"b63700a1ab7e7d47ad1cab80cfe028d2b1b02f1dbf90d4b5108241edd367bea1"}}