{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:3IUEDPPOKBPZA6B7RWOZMR4WC7","short_pith_number":"pith:3IUEDPPO","canonical_record":{"source":{"id":"1808.00595","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-08-01T23:10:27Z","cross_cats_sorted":["math.DS"],"title_canon_sha256":"1c0bc04d3d96149dceb8a2006a85f1ad6773304fc005fc2e7f7fda3b2b57d19b","abstract_canon_sha256":"890f6471c352b3dbe5f4fc7788c24725d495be1d215ad10b227f6ab1485408c1"},"schema_version":"1.0"},"canonical_sha256":"da2841bdee505f90783f8d9d96479617f6867833f4584e62a0dc4911e8588111","source":{"kind":"arxiv","id":"1808.00595","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1808.00595","created_at":"2026-05-17T23:57:14Z"},{"alias_kind":"arxiv_version","alias_value":"1808.00595v2","created_at":"2026-05-17T23:57:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1808.00595","created_at":"2026-05-17T23:57:14Z"},{"alias_kind":"pith_short_12","alias_value":"3IUEDPPOKBPZ","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_16","alias_value":"3IUEDPPOKBPZA6B7","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_8","alias_value":"3IUEDPPO","created_at":"2026-05-18T12:32:02Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:3IUEDPPOKBPZA6B7RWOZMR4WC7","target":"record","payload":{"canonical_record":{"source":{"id":"1808.00595","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-08-01T23:10:27Z","cross_cats_sorted":["math.DS"],"title_canon_sha256":"1c0bc04d3d96149dceb8a2006a85f1ad6773304fc005fc2e7f7fda3b2b57d19b","abstract_canon_sha256":"890f6471c352b3dbe5f4fc7788c24725d495be1d215ad10b227f6ab1485408c1"},"schema_version":"1.0"},"canonical_sha256":"da2841bdee505f90783f8d9d96479617f6867833f4584e62a0dc4911e8588111","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:57:14.995450Z","signature_b64":"991C7FQVNGQSsbHhSVAS2pv6ObNOCmJVIhZYRX9+UbJ33hwxEma/afWnTtK4yOj42ZbLCan8oIu3GWuxp8sUCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"da2841bdee505f90783f8d9d96479617f6867833f4584e62a0dc4911e8588111","last_reissued_at":"2026-05-17T23:57:14.994935Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:57:14.994935Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1808.00595","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:57:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xh/DSxS4NGkFkz8Z7iL2/uE1TheEOuirAIqxZz0qL01A1v9QF/tO7nna95z54GyMD8p6UXbKGb1bX1V9L7YHAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T12:58:16.951125Z"},"content_sha256":"4eb741559e6b413f228700b996daa3189d843b0400e5a397000b38f3d8eccd0f","schema_version":"1.0","event_id":"sha256:4eb741559e6b413f228700b996daa3189d843b0400e5a397000b38f3d8eccd0f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:3IUEDPPOKBPZA6B7RWOZMR4WC7","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Revisiting a synthetic intracellular regulatory network that exhibits oscillations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.DS"],"primary_cat":"q-bio.MN","authors_text":"Anne Shiu, Jay Walton, Jonathan Tyler","submitted_at":"2018-08-01T23:10:27Z","abstract_excerpt":"In 2000, Elowitz and Leibler introduced the repressilator--a synthetic gene circuit with three genes that cyclically repress transcription of the next gene--as well as a corresponding mathematical model. Experimental data and model simulations exhibited oscillations in the protein concentrations across generations. In 2006, M\\\"{u}ller \\textit{et al.}\\ generalized the model to an arbitrary number of genes and analyzed the resulting dynamics. Their new model arose from five key assumptions, two of which are restrictive given current biological knowledge. Accordingly, we propose a new repressilat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1808.00595","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:57:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/SVFY9qJQ4WEy7g+XPclks1pmwojzxUWV4UBU2M/OSJdFom1ESBnehjJfl4jLW1ruPzTrlW+/9Mle44NocZHCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T12:58:16.951501Z"},"content_sha256":"a570a2dfc7f7540e06599cb0eca58af851d60ed4a1d1e723fd358a086276633d","schema_version":"1.0","event_id":"sha256:a570a2dfc7f7540e06599cb0eca58af851d60ed4a1d1e723fd358a086276633d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7/bundle.json","state_url":"https://pith.science/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T12:58:16Z","links":{"resolver":"https://pith.science/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7","bundle":"https://pith.science/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7/bundle.json","state":"https://pith.science/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7/state.json","well_known_bundle":"https://pith.science/.well-known/pith/3IUEDPPOKBPZA6B7RWOZMR4WC7/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:3IUEDPPOKBPZA6B7RWOZMR4WC7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"890f6471c352b3dbe5f4fc7788c24725d495be1d215ad10b227f6ab1485408c1","cross_cats_sorted":["math.DS"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-08-01T23:10:27Z","title_canon_sha256":"1c0bc04d3d96149dceb8a2006a85f1ad6773304fc005fc2e7f7fda3b2b57d19b"},"schema_version":"1.0","source":{"id":"1808.00595","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1808.00595","created_at":"2026-05-17T23:57:14Z"},{"alias_kind":"arxiv_version","alias_value":"1808.00595v2","created_at":"2026-05-17T23:57:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1808.00595","created_at":"2026-05-17T23:57:14Z"},{"alias_kind":"pith_short_12","alias_value":"3IUEDPPOKBPZ","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_16","alias_value":"3IUEDPPOKBPZA6B7","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_8","alias_value":"3IUEDPPO","created_at":"2026-05-18T12:32:02Z"}],"graph_snapshots":[{"event_id":"sha256:a570a2dfc7f7540e06599cb0eca58af851d60ed4a1d1e723fd358a086276633d","target":"graph","created_at":"2026-05-17T23:57:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In 2000, Elowitz and Leibler introduced the repressilator--a synthetic gene circuit with three genes that cyclically repress transcription of the next gene--as well as a corresponding mathematical model. Experimental data and model simulations exhibited oscillations in the protein concentrations across generations. In 2006, M\\\"{u}ller \\textit{et al.}\\ generalized the model to an arbitrary number of genes and analyzed the resulting dynamics. Their new model arose from five key assumptions, two of which are restrictive given current biological knowledge. Accordingly, we propose a new repressilat","authors_text":"Anne Shiu, Jay Walton, Jonathan Tyler","cross_cats":["math.DS"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-08-01T23:10:27Z","title":"Revisiting a synthetic intracellular regulatory network that exhibits oscillations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1808.00595","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4eb741559e6b413f228700b996daa3189d843b0400e5a397000b38f3d8eccd0f","target":"record","created_at":"2026-05-17T23:57:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"890f6471c352b3dbe5f4fc7788c24725d495be1d215ad10b227f6ab1485408c1","cross_cats_sorted":["math.DS"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-08-01T23:10:27Z","title_canon_sha256":"1c0bc04d3d96149dceb8a2006a85f1ad6773304fc005fc2e7f7fda3b2b57d19b"},"schema_version":"1.0","source":{"id":"1808.00595","kind":"arxiv","version":2}},"canonical_sha256":"da2841bdee505f90783f8d9d96479617f6867833f4584e62a0dc4911e8588111","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"da2841bdee505f90783f8d9d96479617f6867833f4584e62a0dc4911e8588111","first_computed_at":"2026-05-17T23:57:14.994935Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:57:14.994935Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"991C7FQVNGQSsbHhSVAS2pv6ObNOCmJVIhZYRX9+UbJ33hwxEma/afWnTtK4yOj42ZbLCan8oIu3GWuxp8sUCQ==","signature_status":"signed_v1","signed_at":"2026-05-17T23:57:14.995450Z","signed_message":"canonical_sha256_bytes"},"source_id":"1808.00595","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4eb741559e6b413f228700b996daa3189d843b0400e5a397000b38f3d8eccd0f","sha256:a570a2dfc7f7540e06599cb0eca58af851d60ed4a1d1e723fd358a086276633d"],"state_sha256":"eff7a799ed319fb53dce53a541f706437215462c6d6f6d7d20d45b39f754b403"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WIU1n7QN34DprDuece+dVv8K+kgxcnFDliP8vUXi60czyhNgKSXaGA+05zlmU5U0zBLkVSqLh71+lf2ywhDsBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T12:58:16.953624Z","bundle_sha256":"8b8e32bdf57f6eef2cf4b31623834bfdea0a8c684477cc808fb1bd16c65f9c83"}}